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Merck

P2508

Sigma-Aldrich

Proflavine hemisulfate salt hydrate

powder

Sinónimos:

3,6-Diaminoacridine hemisulfate salt

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About This Item

Fórmula empírica (notación de Hill):
C13H11N3 · 0.5 H2SO4 · xH2O
Número de CAS:
Peso molecular:
258.29 (anhydrous basis)
Beilstein/REAXYS Number:
3921806
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

form

powder

Quality Level

solubility

H2O: 10 mg/mL

fluorescence

λex 444 nm; λem 508 nm (0.01M HCl)

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[H]O[H].OS(O)(=O)=O.Nc1ccc2cc3ccc(N)cc3nc2c1.Nc4ccc5cc6ccc(N)cc6nc5c4

InChI

1S/2C13H11N3.H2O4S.H2O/c2*14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10;1-5(2,3)4;/h2*1-7H,14-15H2;(H2,1,2,3,4);1H2

InChI key

DTRLDKDFCPUGCA-UHFFFAOYSA-N

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General description

Proflavine is a small, amphipathic, acridine-derived fluorescent dye.Proflavine hemisulfate is used as a rapid stain for cytological studies of biological specimens. It stains cytoplasmic structures and nuclei. Proflavine has the capability to intercalate double stranded DNA.

Application

Proflavine hemisulfate salt hydrate has been used to stain cells of the 1483 cell line. It has also been used as a calibrating dye in fluorescence resonance energy transfer (FRET) analysis.

pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves


Certificados de análisis (COA)

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A Orth et al.
Science advances, 5(4), eaav1555-eaav1555 (2019-04-30)
Optical fiber bundle microendoscopes are widely used for visualizing hard-to-reach areas of the human body. These ultrathin devices often forgo tunable focusing optics because of size constraints and are therefore limited to two-dimensional (2D) imaging modalities. Ideally, microendoscopes would record
Emma V Ainsworth et al.
Chembiochem : a European journal of chemical biology, 17(24), 2324-2333 (2016-09-30)
The transfer of photoenergized electrons from extracellular photosensitizers across a bacterial cell envelope to drive intracellular chemical transformations represents an attractive way to harness nature's catalytic machinery for solar-assisted chemical synthesis. In Shewanella oneidensis MR-1 (MR-1), trans-outer-membrane electron transfer is
Improving spatial resolution of a fiber bundle optical biopsy system
Matthew Kyrish
Proceedings of SPIE (2010)
Robust approaches to quantitative ratiometric FRET imaging of CFP/YFP fluorophores under confocal microscopy
M. R. Tadross
Journal of Microscopy (2009)
Proflavine Hemisulfate as a Fluorescent Contrast Agent for Point-of-Care Cytology
Sandra P. Prieto
PLoS ONE, 10(5) (2015)

Protocolos

Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.

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