N1271

Narasin from Streptomyces auriofaciens

≥98% (HPLC)

• Sinónimos: 4-methylsalinomycin, Monteban, narasin A
• Fórmula empírica (notación de Hill): C₄₃H₇₂O₁₁
• Número de CAS: 55134-13-9
• Peso molecular: 765.03
• Número MDL: MFCD00133653
• Código UNSPSC: 51102829
• ID de la sustancia en PubChem: 24897476
• NACRES: NA.85

Propiedades

• Nivel de calidad: 200
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• solubilidad: methanol: soluble 20 mg/mL
• espectro de actividad antibiótica: Gram-positive bacteria; fungi; viruses
• Modo de acción: cell membrane | interferes
• temp. de almacenamiento: −20°C
• cadena SMILES: CCC(C1OC(C(C)CC1C)C(C)C(O)C(C)C(=O)C(CC)C2OC3(OC4(CCC(C)(O4)C5CCC(O)(CC)C(C)O5)C(O)C=C3)C(C)CC2C)C(O)=O
• InChI: 1S/C43H72O11/c1-12-30(35(46)27(8)34(45)28(9)36-23(4)21-24(5)37(51-36)31(13-2)39(47)48)38-25(6)22-26(7)42(52-38)18-15-32(44)43(54-42)20-19-40(11,53-43)33-16-17-41(49,14-3)29(10)50-33/h15,18,23-34,36-38,44-45,49H,12-14,16-17,19-22H2,1-11H3,(H,47,48)
• Clave InChI: VHKXXVVRRDYCIK-UHFFFAOYSA-N

Descripción

Aplicación

Narasin is a growth-promoting ionophoric antibacterial agent for Enterococci, specifically Enterococcus faecium and Enterococcus faecalis. It inhibits coccidial infection in poultry and mammals and is used in studies involving sodium calcium ion exchange.

Acciones bioquímicas o fisiológicas

Narasin administration in swine results in improved nitrogen digestibility, which decreases fecal nitrogen and increases the relative concentrations of propionic acid in the large intestine. Polyether ionophores, such as Narasin, have a hydrophilic interior and a hydrophobic exterior. The lipophilic ionophore attaches to the lipid rich cell membranes of Gram-positive bacteria. Ionophores bind Na⁺, K⁺, and H⁺ and facilitate their transfer across the bacterial cell membrane, resulting in an increase in H⁺ concentration on the inside of the Gram-positive cell. Therefore, the H⁺ ATPase pump is activated to transport out excess H⁺. The cell is depleted of its energy resources and reduces fermentative functions and cell division .

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H300
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 2 Oral
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges