M3949

MST-312

≥98% (HPLC)

• Sinónimos: N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
• Fórmula empírica (notación de Hill): C₂₀H₁₆N₂O₆
• Número de CAS: 368449-04-1
• Peso molecular: 380.35
• MDL number: MFCD24368986
• UNSPSC Code: 12352200
• PubChem Substance ID: 329817985
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• color: off-white to light tan
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O
• InChI: 1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
• InChI key: MIQUEZGHEJGPJB-UHFFFAOYSA-N

Descripción

Application

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Biochem/physiol Actions

MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable