L6895
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant)
lyophilized powder, TLR ligand tested
Sinónimos:
Monophosphoryl Lipid A from Salmonella
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Productos recomendados
biological source
Salmonella enterica (serotype minnesota Re 595 Re mutant)
Quality Level
form
lyophilized powder
impurities
<0.2% Ketodeoxyoctonate (KDO)
shipped in
ambient
storage temp.
2-8°C
Categorías relacionadas
Application
Lipid A molecules compose the lipid membrane anchoring core components of endotoxins produced by Gram-negative bacteria. Lipid A molecules induce immune responses. Structually, lipid A molecules are composed of two glucosamine units with varied, species dependent, fatty acyl chain numbers and identity and degree of phosphorylation.
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 may be used in comparative assessment of the antigenicity of specific structures within different LPA molecules and analogues.
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 may be used in comparative assessment of the antigenicity of specific structures within different LPA molecules and analogues.
Biochem/physiol Actions
Lipid A has immunostimulatory adjuvant activity including macrophage, T-cell, and B-cell activation. Research has shown Lipid A has greater Th1 than Th2 stimulation.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Subhashini Jagu et al.
Vaccine, 28(28), 4478-4486 (2010-05-04)
Immunization with L1 as pentavalent capsomeres or virus-like particles (VLPs) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (HPV) type from which the vaccine was derived. Conversely, vaccination with L2 minor capsid protein
S Hutchison et al.
Veterinary immunology and immunopathology, 216, 109912-109912 (2019-08-26)
Melanoma in humans and canines is an aggressive and highly metastatic cancer. The mucosal forms in both species share genetic and histopathologic features, making dogs a valuable spontaneous disease animal model. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of
Melissa C Hanson et al.
Vaccine, 33(7), 861-868 (2015-01-07)
An HIV vaccine capable of inducing high and durable levels of broadly neutralizing antibodies has thus far proven elusive. A promising antigen is the membrane-proximal external region (MPER) from gp41, a segment of the viral envelope recognized by a number
Tyler J Van De Voort et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 36(1), 29-40 (2012-12-06)
In this study, an agonistic anti-CD40 monoclonal antibody was combined with monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide and agonist of toll-like receptor-4, to assess the immunomodulatory and antitumor synergy between the 2 agents in mice. Anti-CD40 was
Yanjun Zhang et al.
Antiviral research, 165, 11-22 (2019-03-02)
Respiratory syncytial virus (RSV) infection causes significant disease in the lower respiratory tract of young children, and there is currently no licensed vaccine to prevent RSV infection. The F glycoprotein is considered a major antigenic target for RSV vaccine development.
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico