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L2880

Sigma-Aldrich

Lipopolysaccharides from Escherichia coli O55:B5

purified by phenol extraction

Sinónimos:

LPS

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About This Item

Número de CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352201
NACRES:
NA.25

origen biológico

Escherichia coli (O55:B5)

Nivel de calidad

Formulario

lyophilized powder

purificado por

phenol extraction

técnicas

cell based assay: suitable

impurezas

<3% Protein (Lowry)

color

off-white to tan

solubilidad

water: soluble

aplicaciones

cell analysis
clinical research
life science and biopharma

Condiciones de envío

ambient

temp. de almacenamiento

2-8°C

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Descripción general

Lipopolysaccharides (LPS) are glycolipids, a combination of carbohydrate units linked with single or multiple fatty acids that are found in the cell wall of Gram-negative bacteria. The LPS is an essential component of the outer membrane and the LPS structure is composed of lipid A, a glucosamine-based phospholipid, a short-core oligosaccharide, and an O-antigen, a distal polysaccharide.

Aplicación

Lipopolysaccharide from Escherichia coli O55:B5 has been used:
  • to stimulate hepatocytes and non-parenchymal cells
  • to stimulate the spleen and study the expression of the Malitaf gene in the fish blunt snout bream
  • as part of the concanavalin A (ConA) and D-galactosamine/lipopolysaccharide (D-GalN/LPS) model of fulminant hepatitis to study the effect of the natural compound hesperetin
  • to check the cell viability of human chorionic villi-derived mesenchymal stem cells (hCMSCs) by methyl thiazolyl tetrazolium (MTT) assay
  • to induce oligodendrocyte toxicity to evaluate the neuroprotective effects of few compounds
  • to induce sarcopenia in rats to evaluate the antioxidant effects of curcumin-loaded hydrophobic surface-modified hydroxyapatite
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Acciones bioquímicas o fisiológicas

Lipopolysaccharides (LPS) sets up a protective permeability barrier that blocks the entry of antibiotics and bile salts, which make Gram-negative bacteria innately resistant. LPS is involved in bacterial pathogenicity as the host immune system primarily encounters the LPS component of the bacteria. LPS is an endotoxin and a highly immunogenic antigen that can enhance the immune system. The lipid A of LPS stimulates host cells via toll-like receptors 4 (TLR4).

Otras notas

For additional information on our range of Biochemicals, please complete this form.
For optimal reconstitution of LPS products, an intensive vortex is required before use, regardless of the container type. Ensure that the storage solution concentration is at least 1 mg/ml. While borosilicate (silanized) containers are recommended, polypropylene (PP) plastic containers may also be used.
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictogramas

Skull and crossbones

Palabra de señalización

Danger

Frases de peligro

Clasificaciones de peligro

Acute Tox. 2 Oral

Código de clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)


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Visite la Librería de documentos

A liver microphysiological system of tumor cell dormancy and inflammatory
responsiveness is affected by scaffold properties
Clark AM
Cancer Discovery null
Outer membrane permeability and antibiotic resistance
Delcour A H, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1794(5) , 808-816 (2009)
Promising neuroprotective effects of ?-caryophyllene against LPS-induced oligodendrocyte toxicity: A mechanistic study
Askari V R and Shafiee-Nick R
Biochemical Pharmacology, 159, 154-171 (2019)
The protective effect of the natural compound hesperetin against fulminant hepatitis in vivo and in vitro
Xueting Bai
British Journal of Pharmacology, 174 (2017)
Glycolipid biosurfactants: Biosynthesis and related potential applications in food industry
Ashby R D, et al.
Journal of Separation Science, 307-334 (2023)

Artículos

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

Explore the structure, function, and diverse applications of Lipopolysaccharides. Discover their role in bacteria, serological specificity, and research potential.

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