Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

H1917

Sigma-Aldrich

Histone H1 human

Sinónimos:

Histone, Human

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización


About This Item

Número de CAS:
UNSPSC Code:
12352202
NACRES:
NA.25

biological source

human

Quality Level

recombinant

expressed in E. coli

form

liquid

concentration

1 mg/mL

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... H1.0(3005)

¿Está buscando productos similares? Visita Guía de comparación de productos

General description

Histone H1 is part of high-order chromatin structure and is a linker protein associated with nucleosome core particle. Histone H1 is mapped to human chromosome 6. Histone H1 exists in different isoforms. Histone H1 comprises of N-terminal hydrophobic rich region, central globular domain and a C-terminal with intrinsically disordered regions.

Biochem/physiol Actions

The C-terminal regions of histone H1 is essential for binding to chromatin. The placement of H1 is necessary for nucleosome positioning. Histone H1 maintains chromosome architecture and stabilises compaction of nucleosomes during interphase. H1-null mutants display increased rate of chromatin aberration and growth defects. Histone H1 modulates embryogenesis and DNA repair. The H1 histone undergoes posttranslational modification including phosphorylation, methylation and acetylation, each of which carry out different physiological functions. Histone H1 and its variants contribute to the pathogenesis in cancer, Alzheimer′s disease, male infertility and immunity related disorders.

Physical form

Supplied as 1 mg/mL in 20 mM NaPO4, pH 7.0, 0.3 M NaCl, 1 mM EDTA, and 1 mM DTT.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2

Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Histone H1 null vertebrate cells exhibit altered nucleosome architecture
Hashimoto H, et al.
Nucleic Acids Research, 38(11), 3533-3545 (2010)
Linker Histone in Diseases
Ye X, et al.
International Journal of Biological Sciences, 13(8), 1008-1018 (2017)
H1 histones: current perspectives and challenges
Harshman SW, et al.
Nucleic Acids Research, 41(21), 9593-9609 (2013)
Dynamic placement of the linker histone H1 associated with nucleosome arrangement and gene transcription in early Drosophila embryonic development
Hu J, et al.
Cell Death & Disease, 9(7), 765-765 (2018)
The H1 linker histones: multifunctional proteins beyond the nucleosomal core particle
Hergeth SP and Schneider R
EMBO Reports, 16(11), 1439-1453 (2015)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico