G8134

Gallamine triethiodide

≥98% (TLC), powder, muscarinic receptor antagonist

• Fórmula empírica (notación de Hill): C₃₀H₆₀I₃N₃O₃
• Número de CAS: 65-29-2
• Peso molecular: 891.53
• EC Number: 200-605-1
• MDL number: MFCD00011832
• UNSPSC Code: 12352116
• PubChem Substance ID: 24277837
• NACRES: NA.77

Propiedades

• Quality Level: 200
• assay: ≥98% (TLC)
• form: powder
• mp: 235 °C (dec.) (lit.)
• solubility: H₂O: 100 mg/mL; ethanol: soluble
• storage temp.: 2-8°C
• SMILES string: [I-].[I-].[I-].CC[N+](CC)(CC)CCOc1cccc(OCC[N+](CC)(CC)CC)c1OCC[N+](CC)(CC)CC
• InChI: 1S/C30H60N3O3.3HI/c1-10-31(11-2,12-3)22-25-34-28-20-19-21-29(35-26-23-32(13-4,14-5)15-6)30(28)36-27-24-33(16-7,17-8)18-9;;;/h19-21H,10-18,22-27H2,1-9H3;3*1H/q+3;;;/p-3
• InChI key: REEUVFCVXKWOFE-UHFFFAOYSA-K
• Gene Information: human ... CHRM1(1128) , CHRM2(1129) , CHRM3(1131) , CHRM4(1132) , CHRM5(1133) , CHRNA1(1134) , CHRNB1(1140) , CHRND(1144) , CHRNE(1145) , CHRNG(1146)

Descripción

Application

Gallamine triethiodide has been used:

• as a relaxant for measuring spinal trigeminal nucleus recordings from single neurons.
• as an antagonist in neuroblastoma cells as M2 receptor
• to reduce eye movement during retinal surgery in rat

Biochem/physiol Actions

Gallamine triethiodide has anti-muscarinic effect. It is a competitive antagonist for the muscarinic receptor. Gallamine is regarded as neuromuscular blocking agent.

Muscle relaxant; allosteric muscarinic receptor antagonist with an order of potency of M₂ > M₁ = M₄ > M₃ = M₅. Ligand for the peripheral anionic binding site of acetylcholinesterase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Caution

Hygroscopic

Información de seguridad

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Gloves