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D8161

Sigma-Aldrich

1,4-Dithioerythritol

BioReagent, for molecular biology, ≥99.0%

Sinónimos:

erythro-1,4-Dimercapto-2,3-butanediol, erythro-2,3-Dihydroxy-1,4-butanedithiol, Cleland’s reagent, DTE

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About This Item

Fórmula lineal:
HSCH2CH(OH)CH(OH)CH2SH
Número de CAS:
6892-68-8
Peso molecular:
154.25
Beilstein/REAXYS Number:
1719756
EC Number:
229-998-8
MDL number:
MFCD00063750
UNSPSC Code:
12161504
PubChem Substance ID:
24894196
NACRES:
NA.31

grade

for molecular biology

Quality Level

200

product line

BioReagent

assay

≥99.0%

form

powder

reaction suitability

reagent type: reductant

pH

4.5-6.5 (25 °C, 15.4 g/L)

mp

82-84 °C (lit.)

solubility

water: 50 mg/mL

foreign activity

DNase, Exonuclease detection, RNase, and protease, none detected

storage temp.

2-8°C

SMILES string

O[C@@H](CS)[C@H](O)CS

InChI

1S/C4H10O2S2/c5-3(1-7)4(6)2-8/h3-8H,1-2H2/t3-,4+

InChI key

VHJLVAABSRFDPM-ZXZARUISSA-N

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Application

Reagent for maintaining −SH groups in the reduced state; quantitatively reduces disulfides.
reducing reagent

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H412

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Ta-Lun Kao et al.
Theranostics, 8(10), 2672-2682 (2018-05-19)
Background and Aims: Improving liver regeneration (LR) capacity and thereby liver function reserve is a critical bridging strategy for managing liver failure patients. Since estrogen signaling may participate in LR, our aim was to characterize the roles of ERα and
C Pasquali et al.
Electrophoresis, 18(14), 2573-2581 (1998-04-04)
Electrophoretic techniques, and especially two-dimensional gel electrophoresis (2-DE), have provided an indispensable set of tools for the separation of complex protein mixtures as well as for the identification of protein-protein interactions. Nevertheless, after its introduction more than twenty years ago
I Fialka et al.
Electrophoresis, 18(14), 2582-2590 (1998-04-04)
Protein targeting and sorting is accomplished by complex vesicular transport processes that are tightly regulated within a cell. This is especially important for epithelial cells because correct delivery of newly synthesized proteins as well as recycling and sorting of internalized
András Kolozsi et al.
Inorganic chemistry, 47(9), 3832-3840 (2008-04-03)
The aqueous solutions of arsenous acid with the meso and racemic forms of 1,4-dithiol-butane-2,3-diol, namely, dithioerythritol (dte) and dithiothreitol (dtt), respectively, were titrated pH-metrically in different molar ratios. The p K a values determined for As(OH) 3, and dtt were
Kim H T To et al.
Scientific reports, 10(1), 70-70 (2020-01-11)
The spontaneous contractions of collecting lymphatic vessels provide an essential propulsive force to return lymph centrally. These contractions are driven by an intrinsic electrical pacemaker, working through an unknown underlying ionic mechanism that becomes compromised in some forms of lymphedema.
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