D2141

6-Diazo-5-oxo-L-norleucine

>95% (TLC), suitable for ligand binding assays

• Sinónimos: (S)-2-Amino-6-diazo-5-oxocaproic acid, DON
• Fórmula empírica (notación de Hill): C₆H₉N₃O₃
• Número de CAS: 157-03-9
• Peso molecular: 171.15
• Beilstein: 1725815
• Número MDL: MFCD00037218
• Código UNSPSC: 12352209
• ID de la sustancia en PubChem: 24893639
• NACRES: NA.26

Propiedades

• Nombre del producto: 6-Diazo-5-oxo-L-norleucine, crystalline
• Ensayo: >95% (TLC)
• Nivel de calidad: 200
• Formulario: crystalline
• técnicas: ligand binding assay: suitable
• color: light yellow
• mp: 145 °C
• espectro de actividad antibiótica: neoplastics
• Modo de acción: enzyme | inhibits
• temp. de almacenamiento: −20°C
• cadena SMILES: N[C@@H](CCC(=O)C=[N+]=[N-])C(O)=O
• InChI: 1S/C6H9N3O3/c7-5(6(11)12)2-1-4(10)3-9-8/h3,5H,1-2,7H2,(H,11,12)/t5-/m0/s1
• Clave InChI: YCWQAMGASJSUIP-YFKPBYRVSA-N

Descripción

Descripción general

Chemical structure: amino acid derivatives

Aplicación

6-Diazo-5-oxo-L-norleucine (DON) has been used as an inhibitor of glutamine synthetase–glutamine(amide)-2-oxoglutarate aminotransferase.

Acciones bioquímicas o fisiológicas

6-Diazo-5-oxo-L-norleucine (DON), a glutamine analogue, is used as an inhibitor to study the function, specificity and characteristics of cytidine triphosphate synthase 1(s) (CTPS1) and various glutaminase(s). DON is used to inhibit glutamine (GLN) flux between cells.

DON is associated with a number of reactions involving L-glutamine as a nitrogen source, such as nucleic acid and protein synthesis. It is known to possess anticancer activity against choriocarcinoma.

DON is used to study mechanisms of glutamine utilizing enzymes such as carbamoyl phosphate synthase and cytidine triphosphate synthase.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301 + H311 + H331
• Consejos de prudencia: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Clasificaciones de peligro: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges