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Merck

C9017

Sigma-Aldrich

Concanavalin A from Canavalia ensiformis (Jack bean)

Sepharose conjugate, buffered aqueous suspension

Sinónimos:

ConA

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About This Item

UNSPSC Code:
12161501
NACRES:
NA.32

biological source

Canavalia ensiformis

Quality Level

conjugate

Sepharose conjugate

form

buffered aqueous suspension

contains

20% ethanol as preservative

extent of labeling

10-16 mg per mL

matrix

Sepharose 4B

matrix activation

cyanogen bromide

matrix attachment

amino

matrix spacer

1 atom

capacity

≥25 mg/mL binding capacity (thyroglobulin)

storage temp.

2-8°C

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Application

Used for the purification of glycoproteins containing mannose.

Biochem/physiol Actions

Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.

Physical form

Suspension in 0.1 M acetate buffer, pH 6.0, containing 1 M NaCl, and 1 mM each of CaCl2 , MgCl2, and MnCl2

Analysis Note

Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.

Legal Information

Sepharose is a trademark of Cytiva

Related product

Referencia del producto
Descripción
Precios

pictograms

Health hazard

signalword

Danger

Hazard Classifications

Repr. 2 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

102.2 °F

flash_point_c

39 °C


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jae-Uoong Shim et al.
Inflammation, 32(4), 211-217 (2009-05-06)
Cudrania tricuspidata is one of the most omnipresent traditional herbal drugs for anti-inflammation and anti-tumor. The purpose of the present study was to determine whether the CTB glycoprotein regulates the inflammatory reaction stimulated by bisphenol A (BPA) in human mast
Robert J Huber et al.
Matrix biology : journal of the International Society for Matrix Biology, 31(4), 271-280 (2012-03-07)
CyrA, an extracellular matrix (slime sheath), calmodulin (CaM)-binding protein in Dictyostelium discoideum, possesses four tandem EGF-like repeats in its C-terminus and is proteolytically cleaved during asexual development. A previous study reported the expression and localization of CyrA cleavage products CyrA-C45
Phil-Sun Oh et al.
Journal of cellular biochemistry, 109(1), 124-131 (2009-11-04)
This study investigated the inhibitory effect of a glycoprotein isolated from Cudrania tricuspidata Bureau (CTB glycoprotein) on di(2-ethylhexyl) phthalate (DEHP)-induced mast cell degranulation and related signaling cascade in RBL-2H3 cells. This experiment evaluated the intracellular Ca(2+) level, and the activities
Jin Lee et al.
Journal of cellular biochemistry, 112(2), 694-703 (2011-01-27)
Cadmium is one of the inflammation-related xenobiotics and has been regarded as a potent carcinogen. Gardenia jasminoides Ellis (GJE) has been used to cure inflammation in Korean folk medicine for a long time. The purpose of present study is the
Sei-Jung Lee et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 87, 12-22 (2015-12-04)
This study was carried out to investigate the anti-inflammatory potentials of a 38 kDa glycoprotein isolated from Styrax japonica Siebold et al Zuccarini (SJSZ glycoprotein). We found that SJSZ glycoprotein has concentration-dependent scavenging activity against DPPH and hydroxyl radicals in the cell-free

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