C2313

Compound 48/80

powder,  hypotensive agent

• Sinónimos: Poly-p-methoxyphenethylmethylamine
• UNSPSC Code: 41106300
• NACRES: NA.77

Propiedades

• Nombre del producto: Compound 48/80,
• form: powder
• Quality Level: 200
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C

Descripción

General description

Compound 48/80, is the condensation product of N-methyl p-methoxyphenethylamine and formaldehyde.[1]

Application

Compound 48/80 has been used:

• to stimulate hemocytes for histamine release for measurement in ELISA and flow cytometry[2]
• to induce mast cell degranulation[3]
• to induce anaphylactic activity, dermatitis, pruritis, inflammation in mice[4]

Biochem/physiol Actions

Compound 48/80 (C 48/80) is a hypotensive agent,[1] which promotes release of histamine.[2][1] C 48/80 reduces the phagocytic ability of hemocytes in Styela plicata.[2] C 48/80 promotes degranulation of mast cells.[2][3] It Inhibits calmodulin, phospholipase C, endoplasmic reticulum (ER) Ca²⁺ ATPase and activates G proteins.[1]

Preparation Note

Condensation product of N-methyl-p-methoxyphenethylamine with formaldehyde.

Información de seguridad

• pictograms: GHS06
• signalword: Danger
• hcodes: H301 + H311 + H331
• pcodes: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges