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A263

Sigma-Aldrich

ATPA

solid

Sinónimos:

(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid

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About This Item

Fórmula empírica (notación de Hill):
C10H16N2O4
Número de CAS:
83654-14-2
Peso molecular:
228.25
MDL number:
MFCD01860864
UNSPSC Code:
12352202
PubChem Substance ID:
24277951
NACRES:
NA.77

form

solid

Quality Level

100

color

white

solubility

DMSO: 10 mg/mL
H2O: 2.5 mg/mL

SMILES string

CC(C)(C)c1onc(O)c1CC(N)C(O)=O

InChI

1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15)

InChI key

PIXJURSCCVBKRF-UHFFFAOYSA-N

Gene Information

human ... GRIK1(2897)
rat ... Gria1(50592) , Grik1(29559) , Grin2a(24409)

Biochem/physiol Actions

Selective kainate receptor agonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
MKCQ0867
MKCM8001
MKCK5318
MKBQ2887V
040M1167

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S E Lauri et al.
Neuropharmacology, 41(8), 907-915 (2001-12-19)
The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the
Mai Marie Nielsen et al.
Molecular pharmacology, 63(1), 19-25 (2002-12-19)
Only a few agonists exhibit selectivity between the AMPA and the kainate subtypes of the glutamate receptor. The most commonly used kainate receptor preferring agonist, (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid [(S)-ATPA], is an (R,S)-2-amino-3-(5-methyl-3-hydroxy-4-isoxazolyl)propionic acid (AMPA) derivative in which the methyl group at
Xiaoye Liu et al.
Frontiers in cell and developmental biology, 8, 590-590 (2020-08-01)
Migration of neutrophils across endothelial barriers to capture and eliminate bacteria is served as the first line of innate immunity. Bacterial virulence factors damage endothelium to produce inflammatory cytokines interacts with neutrophils. However, the mechanisms that behind endothelial-neutrophil interaction impact
Alexander Jack et al.
Molecular neurobiology, 56(7), 4960-4979 (2018-11-14)
During neuronal development, AMPA receptors (AMPARs) and NMDA receptors (NMDARs) are important for neuronal differentiation. Kainate receptors (KARs) are closely related to AMPARs and involved in the regulation of cortical network activity. However, their role for neurite growth and differentiation
Nicola Micale et al.
Journal of medicinal chemistry, 45(20), 4433-4442 (2002-09-20)
In this paper we describe the synthesis of a series of novel 2-[(4-alkylsemicarbazono)-(4-aminophenyl)-methyl]-4,5-methylenedioxyphenylacetic acid alkyl esters (10-19) carrying an alkylsemicarbazono moiety at a benzylic site. The influence of this group on the biological activity was evaluated by testing the corresponding
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