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74875

Sigma-Aldrich

8-Octanoyloxypyrene-1,3,6-trisulfonic acid trisodium salt

suitable for fluorescence, ≥90% (HPCE)

Sinónimos:

Trisodium 8-octanoyloxypyrene-1,3,6-trisulfonate

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About This Item

Fórmula empírica (notación de Hill):
C24H21Na3O11S3
Número de CAS:
115787-84-3
Peso molecular:
650.58
MDL number:
MFCD00037628
UNSPSC Code:
12352106
PubChem Substance ID:
57652536
NACRES:
NA.32

Quality Level

100

assay

≥90% (HPCE)

form

powder

mp

251-260 °C (lit.)

solubility

DMF: soluble
DMSO: soluble
H2O: soluble
methanol: soluble

fluorescence

λex 384 nm; λem 409 nm in H2O
λex 460 nm; λem 510 nm in 0.1 M Tris pH 8.0 (esterase)

suitability

suitable for fluorescence

storage temp.

−20°C

SMILES string

[Na+].[Na+].[Na+].CCCCCCCC(=O)Oc1cc(c2ccc3c(cc(c4ccc1c2c34)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O

InChI

1S/C24H24O11S3.3Na/c1-2-3-4-5-6-7-22(25)35-18-12-19(36(26,27)28)15-10-11-17-21(38(32,33)34)13-20(37(29,30)31)16-9-8-14(18)23(15)24(16)17;;;/h8-13H,2-7H2,1H3,(H,26,27,28)(H,29,30,31)(H,32,33,34);;;/q;3*+1/p-3

InChI key

RZVSWISDVXUSGY-UHFFFAOYSA-K

Application

suitable as fluorogenic substrate for esterases, lipases

Other Notes

Highly water soluble enzyme substrate for fluorimetric assay of esterases and lipases at longwave excitation and emission wavelengths

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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O S Wolfbeis et al.
Analytical biochemistry, 129(2), 365-370 (1983-03-01)
A direct and continuous kinetic method for the fluorimetric assay of various hydrolases by using new, highly water-soluble substrates is described. The latter consist of esters of strongly fluorescent 1-hydroxypyren-3,6,8-trisulfonic acid trisodium salt with acetic, butyric, caprylic, and oleic acid.
Kalpit Shah et al.
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Mechanisms that maintain proliferation and delay cell differentiation in the intestinal crypt are not yet fully understood. We have previously shown the implication of histone methylation in the regulation of enterocytic differentiation. In this study, we investigated the role of
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Phagocytosis is responsible for the elimination of particles of widely disparate sizes, from large fungi or effete cells to small bacteria. Though superficially similar, the molecular mechanisms involved differ: engulfment of large targets requires phosphoinositide 3-kinase (PI3K), while that of
Wen-Tao Deng et al.
Human gene therapy, 26(9), 593-602 (2015-06-17)
Our collaborative successful gene replacement therapy using AAV vectors expressing a variant of human RPGR-ORF15 in two canine models provided therapeutic proof of concept for translation into human treatment. The ORF15 sequence contained within this AAV vector, however, has ORF15
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