434R-1

ERG (EP111) Rabbit Monoclonal Primary Antibody

• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: rabbit
• Quality Level: 100; 500
• conjugate: unconjugated
• antibody form: culture supernatant
• antibody product type: primary antibodies
• clone: EP111, monoclonal
• description: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• form: buffered aqueous solution
• species reactivity: human
• packaging: vial of 0.1 mL concentrate (434R-14); vial of 0.5 mL concentrate (434R-15); bottle of 1.0 mL predilute (434R-17); vial of 1.0 mL concentrate (434R-16); bottle of 7.0 mL predilute (434R-18)
• manufacturer/tradename: Cell Marque^™
• technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200
• isotype: IgG
• control: tonsil
• shipped in: wet ice
• storage temp.: 2-8°C
• visualization: nuclear
• Gene Information: human ... ERG(2078)

Descripción

General description

ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.^1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.¹ ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).^1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.¹ ERG has also been observed to be positive in a minority of Ewing sarcomas.² This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).⁵ ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.¹

Quality

IVD

IVD

IVD

RUO

Linkage

ERG Positive Control Slides, Product No. 434S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany