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Key Documents

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T8275

Supelco

Temazepam

analytical standard

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About This Item

Fórmula empírica (notación de Hill):
C16H13ClN2O2
Número de CAS:
846-50-4
Peso molecular:
300.74
EC Number:
212-688-1
MDL number:
MFCD00057904
UNSPSC Code:
41116107
PubChem Substance ID:
329826877
NACRES:
NA.24

grade

analytical standard

Quality Level

200

drug control

USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CN1C(=O)C(O)N=C(c2ccccc2)c3cc(Cl)ccc13

InChI

1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3

InChI key

SEQDDYPDSLOBDC-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

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Categorías relacionadas

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Hypnotic

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H336

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
056F0687V
056F0687
056F0687

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Flunitrazepam

Sigma-Aldrich

F9261

Flunitrazepam

Diazepam-d5 solution 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

D-902

Diazepam-d5 solution

(±)-Ketamine hydrochloride solid

Sigma-Aldrich

K2753

(±)-Ketamine hydrochloride

Gerben Stege et al.
Respiratory medicine, 104(4), 518-524 (2009-11-17)
Benzodiazepines can improve sleep quality, but are also thought to cause respiratory depression in patients with chronic obstructive pulmonary disease (COPD). The aims of this study were to assess the effects of temazepam on indices of circadian respiratory function, dyspnea
Thomas I F H Cremers et al.
The international journal of neuropsychopharmacology, 13(6), 807-811 (2010-01-06)
Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are used as a first-line treatment in depression. However, many depressed patients are also treated with benzodiazepines to alleviate increased anxiety and sleep disturbances normally associated with depression. Since benzodiazepines inhibit 5-HT neuronal firing
R H Medema et al.
Oncogene, 31(21), 2601-2613 (2011-10-04)
DNA-damaging therapies represent the most frequently used non-surgical anticancer strategies in the treatment of human tumors. These therapies can kill tumor cells, but at the same time they can be particularly damaging and mutagenic to healthy tissues. The efficacy of
Temazepam: pharmacological profile of a benzodiazepine and new trends in its clinical application.
F Fraschini et al.
Pharmacological research, 27(2), 97-113 (1993-02-01)
Pablo B Martínez de Morentin et al.
Diabetes, 61(4), 807-817 (2012-02-09)
Smokers around the world commonly report increased body weight after smoking cessation as a major factor that interferes with their attempts to quit. Numerous controlled studies in both humans and rodents have reported that nicotine exerts a marked anorectic action.
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