This product is not tested for solubility and is intended for use as an analytical standard. However, this compound is typically soluble in water at 20 mg/mL. Various sources note that this material is also soluble in DMSO, no concentration is provided. In general, DMSO, at a final concentration of less than 0.5%, is not expected to have a negative impact on cells.
PHR1700
Ribavirin
Pharmaceutical Secondary Standard; Certified Reference Material
Sinónimos:
Ribavirin, 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide
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About This Item
Fórmula empírica (notación de Hill):
C8H12N4O5
Número de CAS:
Peso molecular:
244.20
Número MDL:
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
NACRES:
NA.24
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
grado
certified reference material
pharmaceutical secondary standard
Nivel de calidad
Agency
traceable to BP 593
traceable to Ph. Eur.
traceable to USP 1602706
familia API
ribavirin
CofA
current certificate can be downloaded
envase
pkg of 1 g
técnicas
HPLC: suitable
gas chromatography (GC): suitable
aplicaciones
pharmaceutical (small molecule)
Formato
neat
temp. de almacenamiento
2-8°C
cadena SMILES
NC(=O)c1ncn(n1)[C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O
InChI
1S/C8H12N4O5/c9-6(16)7-10-2-12(11-7)8-5(15)4(14)3(1-13)17-8/h2-5,8,13-15H,1H2,(H2,9,16)/t3-,4-,5-,8-/m1/s1
Clave InChI
IWUCXVSUMQZMFG-AFCXAGJDSA-N
Información sobre el gen
human ... IMPDH1(3614)
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Descripción general
Analog of the imidazole nucleotide intermediates in purine nucleotide biosynthesis.
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards
Ribavirin is a synthetic guanosine analog, effective against respiratory syncytial virus, several hemorrhagic fever viruses and human immuno deficiency virus.[1]Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Aplicación
Ribavirin may be used as a pharmaceutical reference standard for the determination of the analyte in drug dosage forms by high-pressure liquid chromatographic method.[2]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Acciones bioquímicas o fisiológicas
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase, but many other mechanisms of action are also supported with experimental evidence.
Antiviral agent used against a wide variety of human viral infections, in particular, chronic hepatitis C, HIV, and adenovirus. Its metabolite, ribavirin 5′-phosphate, is an inhibitor of inosine monophosphate (IMP) dehydrogenase.
Nota de análisis
These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.
Otras notas
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
Nota al pie de página
To see an example of a Certificate of Analysis for this material enter LRAA6966 in the slot below. This is an example certificate only and may not be the lot that you receive.
Producto relacionado
Referencia del producto
Descripción
Precios
Palabra de señalización
Danger
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Muta. 2 - Repr. 1B
Código de clase de almacenamiento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Intravenous ribavirin and hyperammonemia in an immunocompromised patient infected with adenovirus.
Bertrand P, et al.
Pharmacotherapy, 20(10), 1216-1220 (2000)
Stability-Indicating HPLC-DAD Determination of Ribavirin in Capsules and Plasma.
Haggag RS, et al.
Journal of Chromatographic Science, 52(6), 493-500 (2013)
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