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Merck

PHR1687

Supelco

Ciclohexano

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Cyclohexane

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About This Item

Fórmula empírica (notación de Hill):
C6H12
Número de CAS:
Peso molecular:
84.16
Beilstein/REAXYS Number:
1900225
EC Number:
MDL number:
UNSPSC Code:
12191502
PubChem Substance ID:
NACRES:
NA.24

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grade

certified reference material
pharmaceutical secondary standard

Quality Level

agency

traceable to USP 1601408

vapor density

2.9 (vs air)

vapor pressure

168.8 mmHg ( 37.7 °C)
77 mmHg ( 20 °C)

CofA

current certificate can be downloaded

autoignition temp.

500 °F

expl. lim.

9 %

packaging

ampule of 3x1.2 mL

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

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General description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Cyclohexane is a nonpolar, flammable liquid that belongs to the group of cycloalkanes. In general, cyclohexane is obtained by hydrogenation of benzene and predominately used in the nylon industry.[1] It also finds application in pharmaceutical applications.[2]

Application

Cyclohexane can be used as a pharmaceutical reference standard for residual solvent analysis in pharmaceutical formulations and raw materials by gas chromatography.[3][4]
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAC0291 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Asp. Tox. 1 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

-4.0 °F - closed cup

flash_point_c

-20 °C - closed cup


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    Los clientes también vieron

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    Chromatographia, 56(1), S137-S143 (2002)
    Pervaporation: Membrane Separations
    Encyclopedia of Separation Science, 3636-3641 (2000)
    Validation of a generic analytical procedure for determination of residual solvents in drug substances
    Klick S and Skold A
    Journal of Pharmaceutical and Biomedical Analysis, 36(2), 401-409 (2004)
    Organic solvents in the pharmaceutical industry
    Grodowska K and Parczewski A
    Acta Poloniae Pharmaceutica, 67(1), 3-12 (2010)

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