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916870

Sigma-Aldrich

4-(1-(tert-butoxycarbonyl)piperidin-4-yl)benzoic acid

≥95%

Sinónimos:

Semi-flexible linker for PROTAC® development

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About This Item

Fórmula empírica (notación de Hill):
C17H23NO4
Número de CAS:
149353-75-3
Peso molecular:
305.37
MDL number:
MFCD02178897
UNSPSC Code:
12352106

Quality Level

100

assay

≥95%

form

powder

reaction suitability

reagent type: linker

functional group

Boc
carboxylic acid

storage temp.

2-8°C

SMILES string

O=C(N(CC1)CCC1C(C=C2)=CC=C2C(O)=O)OC(C)(C)C

InChI

1S/C17H23NO4/c1-17(2,3)22-16(21)18-10-8-13(9-11-18)12-4-6-14(7-5-12)15(19)20/h4-7,13H,8-11H2,1-3H3,(H,19,20)

InChI key

YCNVQGGUCDVTIZ-UHFFFAOYSA-N

Application

4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.

Other Notes

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Crosslinkers for Bioconjugation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

related product

Referencia del producto
Descripción
Precios

917605

2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

917362

2-(4-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid, ≥95%

917125

tert-Butyl 4-(4-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917109

2-(3-(1-(tert-butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid

917869

2-(2-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

916617

2-(3-(Piperidin-4-yl)phenyl)acetic acid hydrochloride, ≥95%

916633

(3-(Piperidin-4-yl)phenyl)methanamine dihydrochloride, ≥95%

917591

tert-Butyl 4-(3-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

916889

tert-Butyl 4-(4-(2-aminoethyl)phenyl)piperidine-1-carboxylate, ≥95%

916900

2-(3-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916641

2-(3-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride, 95%

917648

(4-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

916854

2-(Piperidin-4-yl)benzoic acid hydrochloride, 95%

917907

2-(4-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride, ≥95%

917095

4-(Piperidin-4-yl)benzoic acid hydrochloride, ≥95%

917893

(2-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

917656

3-(Piperidin-4-yl)benzoic acid hydrochloride, ≥95%

917168

tert-Butyl 4-(2-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917397

(2-(Piperidin-4-yl)phenyl)methanamine dihydrochloride

917419

2-(2-(Piperidin-4-yl)phenyl)ethan-1-amine dihydrochloride

917354

tert-Butyl 4-(4-(aminomethyl)phenyl)piperidine-1-carboxylate

917141

2-(4-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916625

tert-Butyl 4-(3-(2-aminoethyl)phenyl)piperidine-1-carboxylate, ≥95%

917915

2-(2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)phenyl)acetic acid, ≥95%

917133

(4-(Piperidin-4-yl)phenyl)methanamine dihydrochloride, ≥95%

917400

tert-Butyl 4-(3-(hydroxymethyl)phenyl)piperidine-1-carboxylate, ≥95%

917664

2-(2-(Piperidin-4-yl)phenyl)ethan-1-ol hydrochloride, ≥95%

916897

(3-(Piperidin-4-yl)phenyl)methanol hydrochloride, ≥95%

916846

2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid, 95%

916595

tert-Butyl 4-(4-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

916587

3-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid, ≥95%

917850

tert-Butyl 4-(2-(2-hydroxyethyl)phenyl)piperidine-1-carboxylate, ≥95%

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
MKCV9412

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Andrei A Krysko et al.
Bioorganic & medicinal chemistry letters, 21(19), 5971-5974 (2011-08-20)
The novel RGD mimetics with phthalimidine central fragment were synthesized with the use of 4-piperidine-4-yl-butyric, 4-piperidine-4-yl-benzoic, 4-piperazine-4-yl-benzoic and 1,2,3,4-tetrahydroisoquinoline-7-carboxylic acids as surrogates of Arg motif. The synthesized compounds potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to α(IIb)β(3)
Andrei A Krysko et al.
Bioorganic & medicinal chemistry letters, 26(7), 1839-1843 (2016-02-26)
A series of 2-piperazin-1-yl-quinazolines were synthesized and evaluated for their antiaggregative activity. The synthesized small molecule compounds have potently inhibited platelet aggregation in vitro and blocked FITC-Fg binding to αIIbβ3 integrin in a suspension of washed human platelets. The key
Dominik K Kölmel et al.
ACS combinatorial science, 21(8), 588-597 (2019-07-10)
A new catalytic manifold that merges photoredox with nickel catalysis in aqueous solution is presented. Specifically, the combination of a highly active, yet air-stable, nickel precatalyst with a new electron-deficient pyridyl carboxamidine ligand was key to the development of a
Dillon T Flood et al.
Journal of the American Chemical Society, 141(25), 9998-10006 (2019-05-29)
DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity
Weilin Sun et al.
Journal of medicinal chemistry, 62(6), 3122-3134 (2019-03-16)
Imatinib mesylate, 1a, inhibits production of β-amyloid (Aβ) peptides both in cells and in animal models. It reduces both the β-secretase and γ-secretase cleavages of the amyloid precursor protein (APP) and mediates a synergistic effect, when combined with a β-secretase

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