Saltar al contenido
Merck
Todas las fotos(1)

Key Documents

View All Documentation

551476

Sigma-Aldrich

Q-VD-OPh, Non-O-methylated

≥90% (HPLC), liquid, Caspase inhibitor, Calbiochem®

Sinónimos:

InSolution Q-VD-OPh, Non-O-methylated, N-(2-Quinolyl)valyl-aspartyl-(2,6-difluorophenoxy)methyl Ketone

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Fórmula empírica (notación de Hill):
C26H25F2N3O6
Peso molecular:
513.49
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Q-VD-OPh, Non-O-methylated, InSolution, ≥90%, irreversible broad-spectrum inhibitor of caspases

Quality Level

100

assay

≥90% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

−20°C

General description

A cell-permeable, irreversible, broad-spectrum caspase inhibitor (IC50 = 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively) with effective antiapoptotic properties against all major caspase-mediated cellular apoptosis pathways. Exhibits no cytotoxic effects even at extremely high concentrations. Shown to reduce ischemic brain damage and stroke-induced programmed cell death in thymus and spleen.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
caspase-1
Product does not compete with ATP.
Reversible: no
Target IC50: 50, 100, 430, and <25 nM for caspase-1,-8, -9, and -3, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Sequence

Q-Val-Asp-CH₂-OPh

Physical form

Supplied as a 10 mM (1 mg/195 µl) solution in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Braun, J.S., et al. 2007. Exp. Neurol.206, 183.
Caserta, T.M., et al. 2003. Apoptosis8, 345.
Rebbaa, A., et al. 2003. Oncogene22, 2805.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup - (Dimethylsulfoxide)

flash_point_c

87 °C - closed cup - (Dimethylsulfoxide)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Sara H Small et al.
Science signaling, 14(714), eaba2611-eaba2611 (2021-12-22)
Cytokine production is a critical component of cell-extrinsic responses to DNA damage and cellular senescence. Here, we demonstrated that expression of the gene encoding interleukin-19 (IL-19) was enhanced by DNA damage through pathways mediated by c-Jun amino-terminal kinase (JNK) and
Joshua D Bryant et al.
Current protocols, 2(2), e372-e372 (2022-02-18)
Mitochondria have emerged as key drivers of mammalian innate immune responses, functioning as signaling hubs to trigger inflammation and orchestrating metabolic switches required for phagocyte activation. Mitochondria also contain damage-associated molecular patterns (DAMPs), molecules that share similarity with pathogen-associated molecular
Javier Chicote et al.
Frontiers in pharmacology, 11, 580343-580343 (2020-11-13)
Macroautophagy (hereafter autophagy) is a multistep intracellular catabolic process with pleiotropic implications in cell fate. Attending to its activation, autophagy can be classified into inducible or constitutive. Constitutive, or basal autophagy, unfolds under nutrient-replete conditions to maintain the cellular homeostasis.
Yuanjiu Lei et al.
Cell, 186(14), 3013-3032 (2023-06-24)
Mitochondrial DNA (mtDNA) is a potent agonist of the innate immune system; however, the exact immunostimulatory features of mtDNA and the kinetics of detection by cytosolic nucleic acid sensors remain poorly defined. Here, we show that mitochondrial genome instability promotes

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico