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Documentos clave

5.30389

Sigma-Aldrich

GSK′872

≥98% (HPLC), solid, RIPK3 inhibitor, Calbiochem®

Sinónimos:

RIPK3 Inhibitor, GSK′872, N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine, RIP3 Kinase Inhibitor I, Receptor-Interacting Protein Kinase 3 Inhibitor I, GSK-872, Necrosis Inhibitor V, RIPK3 Inhibitor I

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About This Item

Fórmula empírica (notación de Hill):
C19H17N3O2S2
Número de CAS:
Peso molecular:
383.49
Número MDL:
Código UNSPSC:
12352200
NACRES:
NA.77

Nombre del producto

RIPK3 Inhibitor, GSK′872,

Ensayo

≥98% (HPLC)

Nivel de calidad

Formulario

solid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
protect from light

color

yellow

solubilidad

DMSO: 100 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

[S](=O)(=O)(C(C)C)c1cc2c([nH]cc[c]2=Nc3cc4nc[s]c4cc3)cc1

InChI

1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)

Clave InChI

ZCDBTQNFAPKACC-UHFFFAOYSA-N

Descripción general

A cell-permeable quinolinyl-benzothiazolamine compound that is reported to act as a RIP3-selective kinase inhibitor with >1,000-fold selectivity over a vast majority of more than 300 other kinases, including RIP1. RIP1 inhibitor Nec-1 (30 µM; Cat. Nos. 480065 & 505224 ) and genetic knockdown can be employed in conjunction with GSK′872 (3 µM) in delineating RIP1- vs. RIP3-dependency in Toll-like receptors- (TLRs) mediated necrosis and TNFR1-initiated necroptosis in the presence or absence of caspase inhibitor Z-VAD-FMK (25 µM; Cat. Nos. 627609 & 627610 ). While RIP3 and its downstream substrate MLKL are shown to mediate TLR3-initiated necrosis in the presence of Z-VAD-FMK in murine macrophage (BMDM & J774), fibroblast (3T3-SA & MEF), and endothelial (SVEC4-10) cultures, only in BMDM & J774 macrophage cultures is RIP1 involvement also seen in TLR3-mediated necrosis.

Acciones bioquímicas o fisiológicas

Cell permeable: yes
Primary Target
RIP3 Kinase
Reversible: yes

Envase

Packaged under inert gas

Advertencia

Toxicity: Standard Handling (A)

Reconstitución

Following reconstitution, aliquot and freeze 9-20°C). Stock solutions are stable for up to 3 months at -20°C.

Otras notas

Kaiser, W.J., et al. 2013. J. Biol. Chem.288, 31268.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Yun Wang et al.
Frontiers in cellular and infection microbiology, 9, 286-286 (2019-08-24)
Programmed cell death and especially necroptosis, a programmed and regulated form of necrosis, have been recently implicated in the progression and outcomes of influenza in mouse models. Moreover, Z-DNA/RNA binding protein 1 (ZBP1) has been identified as a key signaling
Lei Wu et al.
Cancer immunology research, 8(5), 710-721 (2020-03-04)
Metabolic reprogramming is critical for the polarization and function of tumor-associated macrophages (TAM) and hepatocarcinogenesis, but how this reprogramming occurs is unknown. Here, we showed that receptor-interacting protein kinase 3 (RIPK3), a central factor in necroptosis, is downregulated in hepatocellular

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