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Documentos clave

420127

Sigma-Aldrich

Jasplakinolide

from Jaspis johnstoni, ≥90% (HPLC), liquid, Actin polymerization promotor, Calbiochem

Sinónimos:

InSolution Jasplakinolide, Jaspis johnstoni

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About This Item

Fórmula empírica (notación de Hill):
C36H45BrN4O6
Peso molecular:
709.67
Código UNSPSC:
12352200
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nombre del producto

Jasplakinolide, Jaspis johnstoni, InSolution, ≥90%, 1 mM in DMSO, mammablian cell mitosis inhibitor, potent inducer of actin polymerization and stabilization

Nivel de calidad

100

Ensayo

≥90% (HPLC)

Formulario

liquid

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

OK to freeze
desiccated (hygroscopic)
protect from light

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

Descripción general

A cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.

Acciones bioquímicas o fisiológicas

Cell permeable: no
Kd = 15 nM for actin binding
Primary Target
F-actin
Product does not compete with ATP.
Reversible: no

Envase

Packaged under inert gas

Advertencia

Toxicity: Harmful (C)

Forma física

A 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.

Reconstitución

Following initial thaw, aliquot and freeze (-20°C).

Otras notas

Rosado, J.A., et al. 2000. J. Biol. Chem.275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem.274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst.87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem.269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother.32, 1154.

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Punto de inflamabilidad (°C)

87 °C - closed cup - (Dimethylsulfoxide)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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