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Merck

H-081

Supelco

7-Hydroxyquetiapine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C21H25N3O3S
Número de CAS:
Peso molecular:
399.51
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

certified reference material

Quality Level

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

OCCOCCN1CCN(C2=NC(C=CC(O)=C3)=C3SC4=C2C=CC=C4)CC1

InChI

1S/C21H25N3O3S/c25-12-14-27-13-11-23-7-9-24(10-8-23)21-17-3-1-2-4-19(17)28-20-15-16(26)5-6-18(20)22-21/h1-6,15,25-26H,7-14H2

InChI key

VEGVCHRFYPFJFO-UHFFFAOYSA-N

General description

A Certified Solution Standard for the primary active metabolite of quetiapine, marketed as the atypical antipsychotic Seroquel® for the treatment of depression, bipolar disorder, and schizophrenia. This new reference standard is suitable for a variety of GCMS and LCMS applications from forensic and forensic toxicology analyisis to urine drug testing. We also offer certified Snap-N-Shoot® solutions of the parent drug Quetiapine fumarate (Q-001) and the internal standard Quetiapine-D8 hemifumarate (Q-002) as well as a wide selection of other atypical antipsychotics and their metabolites and internal standards, such as aripiprazole, clozapine, risperidone, olanzapine, and ziprasidone.

Application


  • Metabolic Analysis of Quetiapine and 7-Hydroxyquetiapine: Research outlined a liquid chromatographic-mass spectrometric procedure specifically developed for analyzing 7-Hydroxyquetiapine alongside quetiapine, validating the method through its application in rat brain and blood samples. This study emphasizes the value of 7-Hydroxyquetiapine in understanding the pharmacokinetics of antipsychotic treatments, crucial for drug metabolism research and therapeutic monitoring (Heisel et al., 2024).

  • Drug Entry and Retention in Hair: An investigative study focused on the distribution of Quetiapine and 7-Hydroxyquetiapine in guinea pig hair roots and shafts post-repeated administration. This work contributes to forensic toxicology by exploring how antipsychotic drugs and their metabolites interact with and are retained in hair, providing insights that support legal and medical inquiries into drug use history (Ji et al., 2021).

  • Single Dose Metabolite Tracking: Research examined the characteristics of quetiapine and 7-Hydroxyquetiapine in hair roots and blood after a single dose, offering a detailed look at the acute phase of metabolite processing in the body. This study aids in forensic analysis and may contribute to better understanding the immediate metabolic responses to quetiapine in clinical scenarios (Yan et al., 2020).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Seroquel is a registered trademark of Astrazeneca UK
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

R H Pullen et al.
Journal of chromatography, 573(1), 49-57 (1992-01-03)
ICI 204,636 (I) is an orally active antipsychotic agent under development for the treatment of schizophrenia in humans. It is partially converted in animals to an active 7-hydroxy metabolite (II). Methods were developed for the simultaneous determination of both analytes

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