850345P

14:0 PC (DMPC)

1,2-dimyristoyl-sn-glycero-3-phosphocholine, powder

• Sinónimos: 1,2-ditetradecanoyl-sn-glycero-3-phosphocholine; DMPC; PC(14:0/14:0)
• Fórmula empírica (notación de Hill): C₃₆H₇₂NO₈P
• Número de CAS: 18194-24-6
• Peso molecular: 677.93
• MDL number: MFCD00036901
• UNSPSC Code: 51191904
• NACRES: NA.25

Propiedades

• assay: >99% (TLC)
• form: powder
• packaging: pkg of 1 × 1 g (850345P-1g); pkg of 1 × 200 mg (850345P-200mg); pkg of 1 × 25 mg (850345P-25mg); pkg of 1 × 500 mg (850345P-500mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 850345P
• lipid type: phospholipids; cardiolipins
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: [O-]P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCC)=O)=O
• InChI: 1S/C36H72NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-35(38)42-32-34(33-44-46(40,41)43-31-30-37(3,4)5)45-36(39)29-27-25-23-21-19-17-15-13-11-9-7-2/h34H,6-33H2,1-5H3/t34-/m0/s1
• InChI key: CITHEXJVPOWHKC-UMSFTDKQSA-N

Descripción

General description

Dimyristoylphosphatidylcholine (DMPC) belongs to the phosphatidylcholine (PCs) family. It is composed of saturated and symmetric phospholipids with 14 carbon atoms.[1] DMPC is zwitterionic glycerophospholipid and is associated with mammalian membranes.[2]

The list of Phosphatidylcholine products offered by Avanti is designed to provide compounds having a variety of physical properties. Products available include short chain (C3-C8 are water soluble and hygroscopic), saturated, multi-unsaturated and mixed acid PC′s. All of the products are purified by HPLC, and special precautions are taken to protect the products for oxidization and hydrolysis.

Application

14:0 PC (DMPC) has been used:

• in the preparation of liposomes for dissipation monitoring[3] and perforin binding and assembly[4] by Quartz crystal microscopy studies.
• in anthraquinone liposomes generation for spectral studies[5]
• in bicelles preparation along with phosphatidylinositol 4,5-bisphosphate for in vitro reconstitution of β2-adrenergic receptor[6]

Biochem/physiol Actions

Dimyristoylphosphatidylcholine (DMPC) in combination with cholesterol is used as biomembrane model.[2] Oral supplementation of DMPC in apolipoprotein (apo) E−null mice, improves high density lipoprotein levels and other lipid profiles, preventing the pathogenesis of atherosclerosis.[7]

Packaging

20 mL Clear Glass Screw Cap Vial (850345P-1g)

20 mL Clear Glass Screw Cap Vial (850345P-500mg)

5 mL Amber Glass Screw Cap Vial (850345P-200mg)

5 mL Amber Glass Screw Cap Vial (850345P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable