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Merck
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Key Documents

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933597

Sigma-Aldrich

Poly(Guluronate)

low endotoxin

Sinónimos:

Alginate, Bioink, Bioprinting, Guluronic Acid, Hydrogel, Ionic, Sodium Alginate

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About This Item

Fórmula lineal:
(C6H8O6)n
UNSPSC Code:
12352201
NACRES:
NA.21

description

GPC 5-15 kDa

Quality Level

100

form

(Solid chunks, fibres or powder)

impurities

<125 EU/g Endotoxin
<5 CFU/g Bioburden(Total aerobic)
<5 CFU/g Bioburden(fungal)

color

white to off-white

storage temp.

2-8°C

Categorías relacionadas

General description

Sodium alginate is a natural linear polysaccharide derived from brown algae made up of blocks of B-D-mannuronate (M) and a-L-guluronate (G). Guluronate blocks that bind Ca2+ cations to form ionic bonds. Poly(guluronate) is isolated from alginate which can be used alone as a stabilizer or further modified to create additional functional groups.

Application

Sodium Alginate based hydrogels are widely used in tissue engineering, 3D bioprinting, and drug delivery applications.

Features and Benefits

  • Sterile, low endotoxin
  • Batch control offers reproducible models for preclinical toxicology testing and drug screening
  • Extended shelf-life & stability

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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K H Bouhadir et al.
Journal of pharmaceutical sciences, 89(7), 910-919 (2000-06-22)
We have incorporated daunomycin, an antineoplastic agent, into a biodegradable hydrogel through a labile covalent bond. In brief, sodium alginate was chemically broken down to low molecular weight and followed by oxidation to prepare poly(aldehyde guluronate). Adipic dihydrazide was used
Kuen Yong Lee et al.
Biomaterials, 25(13), 2461-2466 (2004-01-31)
Hydrogels, chemically cross-linked or physically entangled, have found a number of applications as novel delivery vehicles of drugs and cells. However, the narrow ranges of degradation rates and mechanical strength currently available from many hydrogels limits their applications. We have
David Leal et al.
Carbohydrate polymers, 92(1), 157-166 (2012-12-12)
Graft copolymers were prepared by formation of an amide bond between poly-α-L-guluronic acid (MW 24,000), isolated from sodium alginate and the free amino group of PNIPAAm-NH(2). SEM micrographs revealed the formation of a macroscopic network on the surface of the
K Y Lee et al.
Journal of biomedical materials research, 56(2), 228-233 (2001-05-08)
Degradable and injectable hydrogels may be ideal for bone-tissue engineering, especially in the craniofacial region because of the ease of access for injection. Alginate hydrogels potentially could be used as injectable cell delivery vehicles, but they exhibit a limited range

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