900616

3-(But-3-yn-1-yl)-3-(2-iodoethyl)-3H-diazirine

≥95%

• Sinónimos: Iodo diazirine alkyne, Probe building block
• Fórmula empírica (notación de Hill): C₇H₉IN₂
• Número de CAS: 1450754-38-7
• Peso molecular: 248.06
• MDL number: MFCD29918289
• UNSPSC Code: 12352200

Propiedades

• assay: ≥95%
• form: liquid
• reaction suitability: reaction type: click chemistry
• storage temp.: −20°C

Descripción

Application

Used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and iodine synthetic handle. When appended to a ligand or pharmacophore through its iodinated linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.

Other Notes

Technology Spotlight: Trifuctional Probe Building Blocks

Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases

In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors

"Minimalist" Cyclopropene-Containing Photo-Cross-Linkers Suitable for Live-Cell Imaging and Affinity-Based Protein Labeling

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable