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Key Documents

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421626

Sigma-Aldrich

(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid

97%

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About This Item

Fórmula empírica (notación de Hill):
C10H11NO2
Número de CAS:
74163-81-8
Peso molecular:
177.20
Beilstein/REAXYS Number:
4842199
MDL number:
MFCD00144533
UNSPSC Code:
12352106
PubChem Substance ID:
24866388
NACRES:
NA.22

Quality Level

100

assay

97%

form

solid

optical activity

[α]20/D −168°, c = 1.8 in 1.4 M NaOH

reaction suitability

reaction type: solution phase peptide synthesis

mp

>300 °C (lit.)

application(s)

peptide synthesis

SMILES string

OC(=O)[C@@H]1Cc2ccccc2CN1

InChI

1S/C10H11NO2/c12-10(13)9-5-7-3-1-2-4-8(7)6-11-9/h1-4,9,11H,5-6H2,(H,12,13)/t9-/m0/s1

InChI key

BWKMGYQJPOAASG-VIFPVBQESA-N

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análisis (COA)

Lot/Batch Number
09914LD
10623JR
06727EG
06618MQ
04717LA

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Wei-Jie Fang et al.
Biopolymers, 96(1), 97-102 (2010-06-19)
Peptides containing N-methylamino acids can exhibit improved pharmacodynamic and pharmacokinetic profiles compared to nonmethylated peptides, and therefore interest in these N-methylated peptides has been increasing in recent years. Arodyn (Ac[Phe¹,²,³,Arg⁴,D-Ala⁸]Dyn A(1-11)NH₂) is an acetylated dynorphin A(Dyn A) analog that is
Yingjie Zhang et al.
Bioorganic & medicinal chemistry, 18(5), 1761-1772 (2010-02-23)
Histone deacetylases (HDACs) are enzymes involved in tumor genesis and development. Herein, we report a novel series of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as HDACs inhibitors. The preliminary biological screening showed that most of our compounds exhibited potent inhibitory activity against HDACs.
R Guerrini et al.
Bioorganic & medicinal chemistry, 6(1), 57-62 (1998-03-21)
Substitution of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (Tic) in place of Gly2 in dynorphin A-(1-13)-NH2 and -(1-11)-NH2 (DYN) analogues (1 and 2) decreased the affinity to the kappa, delta, and mu receptors, and kappa selectivity. The analogue [D-Ala2, des-Gly3]DYN (4), a chimera between
D Pagé et al.
Journal of medicinal chemistry, 44(15), 2387-2390 (2001-07-13)
The design, synthesis and pharmacological evaluation of a novel class of Dmt-Tic dipeptide analogues are described. These resulting analogues bearing different C-terminal functionalities were found to bind to the human delta receptor with high affinity. One specific class of dipeptides
Li Li et al.
Nanomedicine : nanotechnology, biology, and medicine, 8(7), 1216-1222 (2012-01-18)
The modification of 3S-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA) with β-cyclodextrin (β-CD) provides an oral antithrombotic agent, 6-(3'S-isoquinoline-3'-carboxylaminoethylamino)-6-deoxy-β-CD (THIQA-β-CD). In aqueous solution THIQA-β-CD undergoes intermolecular inclusion complexation and forms pH-dependent nanostructures. The morphological feature of THIQA-β-CD is a nanocloud consisting of numerous particles
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