184225

Hydrogen fluoride pyridine

pyridine ~30 %, hydrogen fluoride ~70 %

• Sinónimos: HF-Pyridine, Olah′s reagent, PPHF, Poly(pyridine fluoride), Pyridine hydrofluoride, Pyridinium poly(hydrogen fluoride), Pyridinium polybifluoride
• Número de CAS: 62778-11-4
• Beilstein: 4750151
• Número MDL: MFCD00012436
• Código UNSPSC: 12352301
• ID de la sustancia en PubChem: 24851101
• NACRES: NA.22

Propiedades

• Formulario: liquid
• Nivel de calidad: 200
• composición: hydrogen fluoride, ~70% ; pyridine, ~30%
• densidad: 1.1 g/mL at 20 °C (lit.)
• temp. de almacenamiento: −20°C
• cadena SMILES: F[H].c1ccncc1
• InChI: 1S/C5H5N.FH/c1-2-4-6-5-3-1;/h1-5H;1H
• Clave InChI: GRJJQCWNZGRKAU-UHFFFAOYSA-N

Descripción

Descripción general

May contain or form low levels of calcium fluoride during storage. Presence of this does not impact the specification values.

Aplicación

Convenient form of anhydrous HF, stable up to 50°C. Has been used for the preparation of β-fluoroamines from amino alcohols and for the fluorination of acetylenes.
Used together with hypervalent iodine(III) reagents for ipso-fluorination of para-substituted phenols providing cyclohexadienones. Employed with Selectfluor^® (Catalog No. 439479) for geminal fluorination of 2,2-diaryl-1,3-dithiolanes.

Reactant for preparation of:

• Epimers of shikimic acid with the features of fucosylated glycans via zinc-mediated reductive ring opening followed by a Barbier reaction
• Vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure
• Candidates for nucleic acid drugs
• ω-substituted gem-difluoroalkanes by oxidative desulfurization-difluorination

Reagent for:

• Halofluorination reactions

Información legal

Selectfluor is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Pictogramas: GHS06,GHS05
• Palabra de señalización: Danger
• Frases de peligro: H300 + H310 + H330,H314
• Consejos de prudencia: P260 - P270 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Clasificaciones de peligro: Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Eye Dam. 1 - Skin Corr. 1A
• Código de clase de almacenamiento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter