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Merck
  • Structural differences in the brain between wild and laboratory rats (Rattus norvegicus): Potential contribution to wariness.

Structural differences in the brain between wild and laboratory rats (Rattus norvegicus): Potential contribution to wariness.

The Journal of veterinary medical science (2018-05-16)
Ryoko Koizumi, Yasushi Kiyokawa, Kaori Mikami, Akiko Ishii, Kazuyuki D Tanaka, Tsutomu Tanikawa, Yukari Takeuchi
摘要

Wild animals typically exhibit defensive behaviors in response to a wider range and/or a weaker intensity of stimuli compared with domestic animals. However, little is known about the neural mechanisms underlying "wariness" in wild animals. Wild rats are one of the most accessible wild animals for experimental research. Laboratory rats are a domesticated form of wild rat, belonging to the same species, and are therefore considered suitable control animals for wild rats. Based on these factors, we analyzed structural differences in the brain between wild and laboratory rats to elucidate the neural mechanisms underlying wariness. We examined wild rats trapped in Tokyo, and weight-matched laboratory rats. We then prepared brain sections and compared the basolateral complex of the amygdala (BLA), the bed nucleus of the stria terminalis (BNST), the main olfactory bulb and the accessory olfactory bulb. The results revealed that wild rats exhibited larger BLA, BNST and caudal part of the accessory olfactory bulb compared with laboratory rats. These results suggest that the BLA, BNST, and vomeronasal system potentially contribute to wariness in wild rats.

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