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About This Item
经验公式（希尔记法）:
C13H19NO4S
CAS号:
分子量:
285.36
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
推荐产品
等級
pharmaceutical primary standard
API 家族
probenecid
製造商／商標名
USP
應用
pharmaceutical (small molecule)
格式
neat
SMILES 字串
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
InChI
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChI 密鑰
DBABZHXKTCFAPX-UHFFFAOYSA-N
基因資訊
human ... SLC22A11(55867) , SLC22A6(9356) , SLC22A8(9376)
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一般說明
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
應用
Probenecid USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
- Probenecid and Colchicine Tablets
- Probenecid Tablets
分析報告
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他說明
Sales restrictions may apply.
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Clinical pharmacokinetics of probenecid.
Cunningham, R. F., Z. H. Israili, and P. G. Dayton.
Clinical Pharmacokinetics, 6.2, 135-151 (1981)
Probenecid and zidovudine metabolism.
Kornhauser, DavidM, et al.
Lancet, 334.8661, 473-475 (1989)
R F Cunningham et al.
Clinical pharmacokinetics, 6(2), 135-151 (1981-03-01)
A review of the clinical applications and of the disposition of probenecid in man, including drug interactions, is presented. Probenecid is the classical competitive inhibitor of organic acid transport in the kidney and other organs. There are 2 primary clinical
R W Cowdry et al.
Biological psychiatry, 18(11), 1287-1299 (1983-11-01)
Probenecid is used to block the transport of acid monoamine metabolites from cerebrospinal fluid (CSF), on the assumption that the resultant rise in CSF concentrations of the metabolites will reflect presynaptic "turnover" of the parent monoamine. However, CSF levels of
Stephanie E Adamczak et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 34(4), 621-629 (2014-01-09)
The central nervous system (CNS) is an active participant in the innate immune response to infection and injury. In these studies, we show embryonic cortical neurons express a functional, deoxyribonucleic acid (DNA)-responsive, absent in melanoma 2 (AIM2) inflammasome that activates
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