PHR9070

法匹拉韦

certified reference material, TraceCERT^®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

• 别名: 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide, 6-fluoro-3,4-dihydro-3-oxo-2-pyrazinecarboxamide, Avigan, T-705, T705
• 经验公式（希尔记法）: C₅H₄FN₃O₂
• CAS号: 259793-96-9
• 分子量: 157.10
• MDL號碼: MFCD12032148
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: certified reference material; TraceCERT^®
• 品質等級: 300
• 產品線: TraceCERT^®
• 形狀: solid
• 儲存期限: limited shelf life, expiry date on the label
• 製造商／商標名: Manufactured by: Sigma-Aldrich Production GmbH, Switzerland
• 應用: pharmaceutical small molecule
• 儲存溫度: −20°C
• SMILES 字串: FC1=CNC(C(C(N)=O)=N1)=O
• InChI: 1S/C5H4FN3O2/c6-2-1-8-5(11)3(9-2)4(7)10/h1H,(H2,7,10)(H,8,11)
• InChI 密鑰: ZCGNOVWYSGBHAU-UHFFFAOYSA-N

说明

一般說明

This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO 17034. This CRM is traceable to primary material from an NMI, e.g. NIST or NMIJ.
Certified content by quantitative NMR incl. uncertainty and expiry date are given on the certificate.
Download your certificate at: http://www.sigma-aldrich.com

生化／生理作用

Favipiravir (T-705) is an inhibitor of viral RNA polymerase. In cells, the comound is converted to T-705-4-ribofuranosyl-5-triphosphate, which selectively targets the viral polymerase without affecting mammalian RNA or DNA polymerases. Favipiravir inhibits replication of inluenza viruse A, B and C with IC50 values between 0.013 and 0.48 mM. The compound protects mice from lethal-dose infections of wild type and neuraminidase inhibitor-resistant strains of H5N1 viruses, Favipiravir has been found to have activity against many viruses including flavi-, alpha-, filo-, bunya-, arena-, noro-, and of other RNA viruses, and is already used off-label for Ebola and Lassa virus.

推薦產品

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法律資訊

TraceCERT is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS08
• 訊號詞: Warning
• 危險聲明: H341,H361d
• 防範說明: P201 - P202 - P280 - P308 + P313 - P405 - P501
• 危險分類: Muta. 2 - Repr. 2
• 儲存類別代碼: 4.1B - Flammable solid hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable