G1007617

HPLC Analysis of Atorvastatin and Related Compound E on Kromasil^® 5-AmyCoat Chiral

application for HPLC

属性

• 技术: HPLC: suitable
• 试验参数: column: Kromasil 5-AmyCoat, 25 cm x 4.6 mm, 5 μm particles (K08670348); mobile phase: 84:16 hexane: ethanol with 0.1% TFA; flow rate: 1 mL/min; pressure: 1117 psi (77 bar); column temp.: 25 °C; detector: UV, 254 nm; injection: 20 μL; sample: 50 μg/mL atorva
• 适用性: application for HPLC
• 应用: pharmaceutical (small molecule)

说明

分析说明

Atorvastatin calcium also known as HMG-CoA reductase inhibitors in a class of lipid-lowering medications that reduces levels of “bad” cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood and raise “good” cholesterol (high-density lipoprotein, or HDL). The enantiomer of atorvastatin (related compound E) could qualitatively and quantitatively differ in their activities, in pharmacokinetic behavior or pharmacodynamics. The application exhibits baseline resolution under 9 minutes of a racemic mixture of atorvastatin calcium and related compound E on a 5.0 μm Kromasil 5-AmyCoat Chiral.

法律信息

Kromasil is a registered trademark of EKA Chemicals AB

分析物

Atorvastatin related compound E (PHR1872)
Atorvastatin Calcium, Pharmaceutical Secondary Standard; Certified Reference Material