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生物源
human
品質等級
重組細胞
expressed in E. coli
化驗
≥98% (SDS-PAGE)
形狀
powder
效力
1-10 ng/mL ED50/EC50
品質
endotoxin tested
分子量
protein 38.2 kDa (as homodimer)
包裝
pkg of 10 μg
儲存條件
avoid repeated freeze/thaw cycles
技術
cell culture | mammalian: suitable
雜質
≤0.1 EU/μg
顏色
white
溶解度
water: soluble
UniProt登錄號
儲存溫度
−20°C
基因資訊
human ... VEGFA(7422)
一般說明
Vascular Endothelial Growth Factor (VEGF) gene is localized to human chromosome 6p21.3, and is thought to encode four different isoforms.
應用
Vascular Endothelial Growth Factor (VEGF) has been used for-
- the determination of oligodendrocyte precursor cells (OPCs) and luteal cell proliferation/survival
- inducing proliferation of epithelial cell clusters (ECCs) to be transplanted into mice
生化／生理作用
Vascular Endothelial Growth Factor (VEGF), also known as vasculotropin, is an angiogenic growth factor, which is heat and acid stable. VEGFs stimulate endothelial cell growth, angiogenisis, and capillary permeability. VEGF is a secreted homodimeric, heparin-binding glycoprotein,1 which has an isoelectric point of 8.5. VEGF promotes the growth of endothelial cells isolated from bovine adrenal cortex, cerebral cortex, fetal and adult aorta, and human umbilical vein. The target cell specificity of VEGF is restricted to vascular endothelial cells. VEGF has no mitogenic effect on cultured corneal endothelial cells, vascular smooth muscle cells, BHK-12 fibroblasts, keratinocytes, human sarcoma cells, or lens epithelial cells. A variety of human tumor cell lines including sarcoma and carcinoma cells show a 3.7 kb RNA transcript that hybridizes with the VEGF probe in a Northern blot. Mouse sarcoma 180 cells express the VEGF mRNA and secrete a VEGF-like mitogen.
VEGF recombinant protein might have potential as a therapeutic agent in treatment-resistant disorders, where it can facilitate endothelial cell growth and vessel formation.
VEGF recombinant protein might have potential as a therapeutic agent in treatment-resistant disorders, where it can facilitate endothelial cell growth and vessel formation.
物理性質
Monomer consists of 165 amino acid residues, approx. mol. weight 19.2 kDa
外觀
Lyophilized from a sterile filtered buffered solution with no additives.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Samara S Souza et al.
PloS one, 15(11), e0241442-e0241442 (2020-11-05)
Heterotopic and orthotopic ovarian tissue autotransplantation techniques, currently used in humans, will become promising alternative methods for fertility preservation in domestic and wild animals. Thus, this study describes for the first time the efficiency of a heterotopic ovarian tissue autotransplantation
Behrous Davani et al.
Stem cells (Dayton, Ohio), 25(12), 3215-3222 (2007-09-29)
Islet transplantation offers improved glucose homeostasis in diabetic patients, but transplantation of islets is limited by the supply of donor pancreases. Undifferentiated precursors hold promise for cell therapy because they can expand before differentiation to produce a large supply of
G Conn et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(4), 1323-1327 (1990-02-01)
A growth factor that is mitogenic for vascular endothelial cells, with an ED50 of approximately 1 ng/ml, has been purified 170,000-fold to apparent homogeneity from tissue culture medium conditioned by a rat glioma-derived cell line. The pure protein is a
Alexander T Bauer et al.
Blood, 125(20), 3153-3163 (2015-05-16)
Tumor-mediated procoagulatory activity leads to venous thromboembolism and supports metastasis in cancer patients. A prerequisite for metastasis formation is the interaction of cancer cells with endothelial cells (ECs) followed by their extravasation. Although it is known that activation of ECs
Michael Bressan et al.
Development (Cambridge, England), 141(21), 4149-4157 (2014-10-03)
Efficient blood flow depends on two developmental processes that occur within the atrioventricular junction (AVJ) of the heart: conduction delay, which entrains sequential chamber contraction; and valve formation, which prevents retrograde fluid movement. Defects in either result in severe congenital
商品
VEGF-A stimulates blood vessel growth via endothelial cell proliferation, migration, and survival during embryonic development.
Cell based angiogenesis assays to analyze new blood vessel formation for applications of cancer research, tissue regeneration and vascular biology.
在癌症研究、组织再生和血管生物学应用中通过以细胞为基础的血管生成检测来分析新血管的形成。
Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.
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