推荐产品
生物源
rabbit
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 60 kDa
物種活性
human
技術
microarray: suitable
western blot (chemiluminescent): 1:1,000 using synaptic vesicle (SV) fraction of rat brain.
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... SLC17A7(57030)
一般說明
VGLUT1 (vesicular glutamate transporter 1, originally termed BNPI and characterized as a Na+/Pi transporter) is a 60 kDa protein. VGLUT2 is enriched in synaptic vesicles and selective for a distinct class of glutaminergic nerve terminals.
Vesicular glutamate transporter 1 (VGLUT1), also called as solute carrier family 17 member 7 (SLC17A7), is encoded by the gene mapped to human chromosome 19q13, a region associated with schizophrenia. VGLUT1 is specifically expressed in neuronal cells in the brain and at higher levels in neuron-enriched regions such as the amygdala and hippocampus. Glia-enriched areas such as the corpus callosum also show moderate level of expression and substantia nigra, subthalamic nuclei and thalamus show low level expression. VGLUT1 is characterized with a conserved C-terminal dileucine-like motif and two polyproline domains distal to C- terminal end, including one that binds to endocytic BAR (Bin/Amphiphysin/Rvs) domain protein, endophilin.
免疫原
synthetic peptide corresponding to a region near the C-terminus of human VGLUT1 (amino aicds 504-520).
生化／生理作用
Vesicular glutamate transporter 1 (VGLUT1) is associated with neuronal pathways that exhibit activity-dependent potentiation, whereas VGLUT2 is expressed in sensory and autonomic pathways that display high fidelity neurotransmission.
Vesicular glutamate transporter 1 (VGLUT1) plays a vital role as a vesicular glutamate transporter in glutamatergic neurons. VGLUT1 expression in the prefrontal cortex functions as a potential neurochemical marker of dementia in Alzheimer′s disease (AD) and antidepressant activity.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
VGLUTs in peripheral neurons and the spinal cord: time for a review
Brumovsky PR
ISRN neurology, 2013 (2013)
Alireza Kashani et al.
Neurobiology of aging, 29(11), 1619-1630 (2007-05-29)
Several lines of evidence suggest that the glutamatergic system is severely impaired in Alzheimer disease (AD). Here, we assessed the status of glutamatergic terminals in AD using the first available specific markers, the vesicular glutamate transporters VGLUT1 and VGLUT2. We
Larissa Moutsimilli et al.
Neuropharmacology, 49(6), 890-900 (2005-08-23)
The two recently characterized vesicular glutamate transporters (VGLUT) presynaptically mark and differentiate two distinct excitatory neuronal populations and thus define a cortical and a subcortical glutamatergic system (VGLUT1 and VGLUT2 positive, respectively). These two systems might be differentially implicated in
L Bai et al.
The Journal of biological chemistry, 276(39), 36764-36769 (2001-07-04)
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. Packaging and storage of glutamate into glutamatergic neuronal vesicles requires ATP-dependent vesicular glutamate uptake systems, which utilize the electrochemical proton gradient as a driving force. VGLUT1, the first
Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3.
Y Aihara et al.
Cytogenetics and cell genetics, 92(1-2), 167-169 (2001-04-18)
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