推荐产品
product name
(±)-Bufuralol hydrochloride,
形狀
solid
顏色
white to off-white
mp
143-146 °C
溶解度
H2O: soluble
methanol: soluble
儲存溫度
2-8°C
SMILES 字串
Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C
InChI
1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H
InChI 密鑰
KJBONRGCLLBWCJ-UHFFFAOYSA-N
應用
CYP2D6 substrate
生化／生理作用
Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
β-Blocker. Varying β-adrenoceptor agonist/antagonist activity.
特點和優勢
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
包裝
Bottomless glass bottle. Contents are inside inserted fused cone.
準備報告
(±)-Bufuralol hydrochloride is soluble in water and methanol.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
D Magometschnigg et al.
International journal of clinical pharmacology and biopharmacy, 17(11), 429-432 (1979-11-01)
In this hemodynamic study a new beta-receptor blocker, Bufuralol-hydrochloride was compared with Pindolol under an Isoproterenol infusion with increasing doses in healthy male volunteers. We found the following results: 1. Before Isoproterenol peripheral resistance increased after acute i.v. application of
Jialin Mao et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(4), 706-716 (2012-01-10)
Cryopreserved human hepatocytes suspended in human plasma (HHSHP) have previously provided accurate CYP3A drug-drug interaction (DDI) predictions from a single IC(50) that captures both reversible and time-dependent inhibition. The goal of this study was to compare the accuracy of DDI
Sami Haddad et al.
Journal of pharmaceutical sciences, 99(10), 4406-4426 (2010-03-24)
Drug-drug interactions (DDIs) are a great concern to the selection of new drug candidates. While in vitro screening assays for DDI are a routine procedure in preclinical research, their interpretation and relevance for the in vivo situation still represent a
Kazuhide Iwasaki et al.
Drug metabolism and pharmacokinetics, 25(4), 388-391 (2010-09-04)
Drug metabolizing activities of cytochromes P450 (P450s, or CYPs) 3A4 and 3A5 in liver microsomes from the cynomolgus monkey [Macaca fascicularis (mf)] were investigated and compared with those of human P450 3A enzymes. Low activities for dealkylation of ethoxyresorufin and
Yasuhiro Uno et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(9), 1486-1492 (2010-05-27)
The cynomolgus monkey is used in drug metabolism studies, because of its evolutionary closeness to human, including cytochrome P450. Cynomolgus monkey CYP2D17, highly homologous to human CYP2D6, has been identified and characterized. Here, we report characterization of another CYP2D, CYP2D44
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