重組細胞
expressed in E. coli
品質等級
化驗
≥95% (SDS-PAGE)
形狀
liquid
分子量
18 kDa
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... UBE2G2(7327) , UBE2L3(7332)
一般說明
Manufactured for Sigma by Boston Biochem., Inc.
生化／生理作用
Acts in conjunction with Ubc6 to degrade MAT α2 factor.
May act in both the degradation of non-N-end rule protein substrates and of certain Nα-acetylated proteins as well as the degradation of tumor suppressor protein p53.
外觀
Solution in 50 mM HEPES, pH 8.0, 50 mM NaCl, 1 mM DTT in 10% glycerol.
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
P Chen et al.
Cell, 74(2), 357-369 (1993-07-30)
Attachment of ubiquitin to proteins is catalyzed by a family of ubiquitin-conjugating (UBC) enzymes. Although these enzymes are essential for many cellular processes; their molecular functions remain unclear because no physiological target has been identified for any of them. Here
Jian Wang et al.
The Journal of biological chemistry, 285(16), 12279-12288 (2010-02-23)
Nedd4 E3 ligases are members of the HECT E3 ubiquitin ligase family and regulate ubiquitination-mediated protein degradation. In this report, we demonstrate that calcium releases the C2 domain-mediated auto-inhibition in both Nedd4-1 and Nedd4-2. Calcium disrupts binding of the C2
Evangelia Koutelou et al.
The Journal of biological chemistry, 283(7), 3846-3853 (2007-12-14)
Notch signaling constitutes an evolutionarily conserved mechanism that mediates cell-cell interactions in various developmental processes. Numerous regulatory proteins interact with the Notch receptor and its ligands and control signaling at multiple levels. Ubiquitination and endocytosis followed by endosomal sorting of
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