化驗
≥98%
效力
2.4 μM IC50
溶解度
DMSO: soluble 50 mg/mL, clear, orange
ethanol: soluble
儲存溫度
2-8°C
SMILES 字串
NC(=S)\C(=C\c1ccc(O)c(O)c1)C#N
基因資訊
human ... CDK2(1017) , EGFR(1956)
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應用
Tyrphostin 47 has been used in LOPAC screening assays to identify human tissue transglutaminase (TGM2) inhibitors. Tyrphostin 47 has also been used to study its effects on hyperpolarization-activated cation current in porcine pacemaker cells.
生化／生理作用
Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
EGFR tyrosine kinase inhibitor.
準備報告
Tyrphostin 47 is is soluble in DMSO (50 mg/ml) and yields a clear, orange solution. The product is also soluble in ethanol (40 mM).
訊號詞
Warning
危險聲明
危險分類
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Maribel Diaz-Ricart et al.
Thrombosis research, 121(6), 873-883 (2007-10-02)
Platelet activation leads to signal transduction mechanisms, in which phosphotyrosine proteins play a relevant role. Platelet suspensions were independently activated by collagen and thrombin in the absence and in the presence of two tyrosine kinase inhibitors, tyrphostin 47 and genistein.
Naoki Kimura et al.
Bioconjugate chemistry, 18(6), 1778-1785 (2007-10-24)
The present study reported proof-of-principle for a kinase assay approach that can detect specific peptide phosphorylation events. The method involves attachment of peptides onto commercial aminosilane and polycarbodiimide-coated glass slides, using a newly developed DNattach linker system that consists of
Yorimasa Ogata et al.
Cell biology international, 27(8), 689-693 (2003-07-18)
Bradykinin (1 microM) and histamine (100 microM) evoked an initial transient increase and a subsequent sustained increase in intracellular Ca(2+) concentration ([Ca(2+)](i)) in fura-2-loaded human gingival fibroblasts, which may be attributed to Ca(2+) release from intracellular stores and Ca(2+) entry
Jun Takeda et al.
Development, growth & differentiation, 44(6), 501-508 (2002-12-21)
During the development of the chicken proventriculus (glandular stomach), the initially undifferentiated epithelium differentiates into two distinct cell populations: the glandular epithelium, cells of which secrete embryonic chicken pepsinogen (ECPg), and luminal epithelial cells, which express the chicken spasmolytic polypeptide
S Shibata et al.
British journal of pharmacology, 128(6), 1284-1290 (1999-12-01)
1 The hyperpolarization-activated cation current (If) was recorded in single pacemaker cells of the porcine sino-atrial node, and the effects of genistein, an isoflavone inhibitor of tyrosine-specific protein kinases was investigated by the whole-cell patch clamp technique. 2 Genistein (20-500
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