所有图片(1)
About This Item
经验公式（希尔记法）:
C16H14N2O2
CAS号:
分子量:
266.29
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
方案
≥98%
表单
solid
效能
IC50 (3 micromolar for inhibition of EGF-receptor.)
mp
114-115 °C
溶解性
DMSO or ethanol: soluble
储存温度
2-8°C
SMILES字符串
COc1ccc(cc1OC)\C=C(\C#N)c2cccnc2
InChI
1S/C16H14N2O2/c1-19-15-6-5-12(9-16(15)20-2)8-14(10-17)13-4-3-7-18-11-13/h3-9,11H,1-2H3
InChI key
DBGZNJVTHYFQJI-UHFFFAOYSA-N
生化/生理作用
Non-phenolic tyrphostin-class tyrosine kinase inhibitor.
制备说明
Tyrphostin RG 13022 is known to suppress EGF-induced cancer cell proliferation under in vitro conditions and can also inhibit the growth of tumors in nude mice.
Tyrphostin RG 13022 is soluble in DMSO and ethanol.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
L F Gulli et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 7(2), 173-178 (1996-02-01)
A431 cells overexpress epidermal growth factor receptors (EGF-Rs) and are inhibited by EGF. We show that treatment of A431 cells with 10 nM EGF induced a 15-fold increase in EGF-R autophosphorylation, leading to inhibition of cell proliferation and morphological features
W Xian et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 6(11), 1447-1455 (1995-11-01)
The present study was designed to further investigate the role of the epidermal growth factor receptor (EGFr) in mouse skin tumor promotion by evaluating the status of the EGFr in tumor promoter-treated mouse epidermis and in mouse skin tumors. Female
B S Kondapaka et al.
Molecular and cellular endocrinology, 117(1), 53-58 (1996-03-01)
In prostate cancer cells, the binding of peptide growth factors to specific receptors increases tyrosine kinases (TK) activity to regulate cell proliferation, cell differentiation, and signaling processes. To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied
K B Reddy et al.
Cancer research, 52(13), 3636-3641 (1992-07-01)
Human breast cancer cell proliferation is regulated by growth factors that bind to receptors with intrinsic tyrosine kinase (TK) activity, including the epidermal growth factor (EGF) receptor. To determine whether inhibition of receptor TK activity inhibits tumor growth, we studied
T Yoneda et al.
Cancer research, 51(16), 4430-4435 (1991-08-15)
Many human tumors of epithelial origin contain cells overexpressing the epidermal growth factor (EGF) receptor, and there is convincing evidence that cancer cell growth is correlated with the loss of the normal regulation of the EGF receptor signal transduction pathway.
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