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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
mp
132-132.5 °C
溶解度
DMSO: 33 mg/mL
儲存溫度
2-8°C
SMILES 字串
CCN1\C(Sc2ccc(OC)cc12)=C\C(C)=O
InChI
1S/C13H15NO2S/c1-4-14-11-8-10(16-3)5-6-12(11)17-13(14)7-9(2)15/h5-8H,4H2,1-3H3/b13-7-
InChI 密鑰
BGVLELSCIHASRV-QPEQYQDCSA-N
應用
TG003已被用于PAC1细胞培养和体外激酶检测中。
TG003已被用于开发可影响mRNA剪接1的筛选底物的检测体系。
生化/生理作用
TG003可调节可变剪接并降低SF2/ASF1的磷酸化。
TG003,一种CLK(cdc2样激酶)家族抑制剂,可用作杜氏肌营养不良症的药物。
Cdc2样激酶(Clk)的有效、特异、可逆及ATP竞争性抑制剂。对于mClk1/Sty的Ki = 10 nM;对于mClk4、mClk1、mClk2和mClk3分别的IC50 = 15 nM、20 nM、200 nM和> 10 mM。
包裝
在氮气保护下封装。
準備報告
TG003可以33 mg/ml溶于DMSO。
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Pharmacological reviews, 69(1), 63-79 (2016-12-31)
More than 95% of genes in the human genome are alternatively spliced to form multiple transcripts, often encoding proteins with differing or opposing function. The control of alternative splicing is now being elucidated, and with this comes the opportunity to
Deciphering targeting rules of splicing modulator compounds: case of TG003
BMC Molecular Biology, 16(1), 16-16 (2015)
The TORC1-Regulated CPA Complex Rewires an RNA Processing Network to Drive Autophagy and Metabolic Reprogramming
Cell Metabolism, 27(5), 1040-1054 (2018)
The alternative splicing program of differentiated smooth muscle cells involves concerted non-productive splicing of post-transcriptional regulators
Nucleic Acids Research, 44(18), 8933-8950 (2016)
Bioscience, biotechnology, and biochemistry, 76(6), 1248-1251 (2012-07-14)
A number of proteins complete mRNA processing in the nucleus, thus, inhibitor of mRNA processing is worth finding to analyze the mechanism of mRNA maturation in detail. Here, we established a monitoring system for mRNA processing using a test compound
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