方案
≥95%
溶解性
H2O: soluble 50 mg/mL, clear, yellow to very deep yellow
储存温度
−20°C
SMILES字符串
[Na+].NC(=S)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)([O-])=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
InChI
1S/C21H28N7O16P3S.Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(43-45(32,33)34)14(30)11(42-21)6-40-47(37,38)44-46(35,36)39-5-10-13(29)15(31)20(41-10)27-3-1-2-9(4-27)18(23)48;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,48);/q;+1/p-1/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1
InChI key
RFGBSJGYGUYCBT-QYZPTAICSA-M
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应用
Thio-NADP has been identified as a compound unique to the β-arrestin CNR2 screening assay4.
生化/生理作用
Blocks nicotinate adenine dinucleotide phosphate (NAADP)-induced Ca2+ release
Studies using sea-urchin egg homogenates have reported that thio-NADP stimulates partial Ca2+ release at 50 μm and blocks successive challenge with a saturating concentration of nicotinic acid adenine dinucleotide phosphate (NAADP). Subsequent HPLC purification analysis have reported that Ca2+ release function of thio-NADP is because of the presence of NAADP as a contaminant. Hence, this study challenges the NAADP antagonist functions of thio-NADP and indicates that thio-NADP does not function as an NAADP blocker5.
联系
Analog of NADP
制备说明
Thionicotinamide adenine dinucleotidephosphate (thio-NADP) sodium is soluble in water at 50 mg/ml and yields a clear, yellow to dark yellow solution.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
D M Dickey et al.
Cell biochemistry and biophysics, 28(1), 63-73 (1997-12-05)
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a metabolite of NADP, which can release Ca2+ from stores that are distinct from those activated by either cyclic ADP-ribose or inositol 1,4,5-trisphosphate (IP3). It has previously been suggested that thio-NADP is a
S Gupta et al.
Biochimica et biophysica acta, 1409(1), 25-38 (1998-11-07)
The effects of single amino acid substitutions in the mobile loop region of the recombinant NAD(H)-binding domain (dI) of transhydrogenase have been examined. The mutations lead to clear assignments of well-defined resonances in one-dimensional 1H-NMR spectra. As with the wild-type
K Iizuka et al.
The Journal of physiology, 511 ( Pt 3), 915-933 (1998-08-26)
1. To examine the contributions of the putative Ca2+ releasers, inositol 1,4,5-trisphosphate (InsP3), cyclic ADP ribose (cADPR), and nicotinate adenine dinucleotide phosphate (NAADP), to carbachol (CCh)-induced contraction in airway smooth muscle, we measured force development of permeabilized rabbit tracheal smooth
J Feeney et al.
Biochemistry, 22(3), 628-633 (1983-02-01)
Transferred nuclear Overhauser effect measurements have been made on complexes of NADP+ and thioNADP+ with Lactobacillus casei dihydrofolate reductase to provide information about the glycosidic bond conformations in these complexes. Both NADP+ and thioNADP+ are shown to have very similar
Arkady S Pivovarov et al.
Regulatory peptides, 111(1-3), 31-39 (2003-03-01)
The effect of seven compounds intracellularly applied by spontaneous diffusion were investigated on the EPYLRFamide-induced reduction of acetylcholine-induced inward current (ACh-current) recorded from identified neurones from Helix lucorum. Inward currents were recorded from neurones LPa2, LPa3, RPa3 and RPa2 in
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