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Merck

T1505

Sigma-Aldrich

四异丙基焦磷酸亚胺

butyrylcholinesterase inhibitor

别名:

四(单阳离子基)焦磷酸四胺, 异-OMPA

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About This Item

经验公式(希尔记法):
C12H32N4O3P2
CAS号:
分子量:
342.36
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic

mp

149-151 °C

储存温度

−20°C

SMILES字符串

CC(C)NP(=O)(NC(C)C)OP(=O)(NC(C)C)NC(C)C

InChI

1S/C12H32N4O3P2/c1-9(2)13-20(17,14-10(3)4)19-21(18,15-11(5)6)16-12(7)8/h9-12H,1-8H3,(H2,13,14,17)(H2,15,16,18)

InChI key

IOIMDJXKIMCMIG-UHFFFAOYSA-N

基因信息

应用

四异丙基焦磷酰胺已被用于:
  • 作为丁酰胆碱酯酶抑制剂,用于测定猫和虎血浆中丁酰胆碱酯酶 (BChE) 的比例
  • 在乙酰胆碱酯酶测定中抑制野生型 BChE
  • 选择性阻断 AChE 的酶活性

生化/生理作用

丁酰胆碱酯酶的选择性抑制剂

警告

警告:极其危险!在使用本产品之前,请注意风险并熟悉安全程序。

象形图

Skull and crossbones

警示用语:

Danger

危险声明

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

储存分类代码

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Resistance to organophosphorus agent toxicity in transgenic mice expressing the G117H mutant of human butyrylcholinesterase
Wang YW, et al.
Toxicology and Applied Pharmacology, 196(3), 356-366 (2004)
Determination of the DNA sequences of acetylcholinesterase and butyrylcholinesterase from cat and demonstration of the existence of both in cat plasma.
Bartels CF, et al.
Biochemical Pharmacology, 60(4), 479-487 (2018)
Liyi Geng et al.
PloS one, 8(6), e67446-e67446 (2013-07-11)
Gene transfer of a human cocaine hydrolase (hCocH) derived from butyrylcholinesterase (BChE) by 5 mutations (A199S/F227A/S287G/A328W/Y332G) has shown promise in animal studies for treatment of cocaine addiction. To predict the physiological fate and immunogenicity of this enzyme in humans, a
Postnatal development of nitrergic and cholinergic structures in rat spinal cord
Bolekova A, et al.
Archives Italiennes de Biologie, 149(3), 293-302 (2011)
Magali Rault et al.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology, 147(2), 340-346 (2007-03-10)
To validate cholinesterase activity as a biomarker of pesticide exposure, we characterized the tissue distribution (whole body, nervous tissue and crop/gizzard), activity at two seasons of cholinesterase in six different species of earthworms collected in an unpolluted field: Lumbricus terrestris

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