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Merck
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Key Documents

SRP6590

Sigma-Aldrich

Core Histones human

≥95% (SDS-PAGE)

别名:

HeLa Core Histones

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About This Item

分類程式碼代碼:
12352200
NACRES:
NA.32

生物源

human

化驗

≥95% (SDS-PAGE)

形狀

liquid

包裝

pkg of 50 and 100 μg

濃度

1 mg/mL

技術

cell based assay: suitable

運輸包裝

dry ice

儲存溫度

−70°C

一般說明

A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Further, histone H1 combines with these histones to form 30nm fibers. These fibers have six nucleosomes per turn in a solenoid arrangement. Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.

外觀

50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Sens. 1

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.
Zhang Y and Reinberg D
Genes & Development, 15(18), 2343-2360 (2001)
Roberto Fabian et al.
Molecules (Basel, Switzerland), 26(16) (2021-08-28)
We report data from single molecule studies on the interaction between single DNA molecules and core histones using custom-designed horizontal magnetic tweezers. The DNA-core histone complexes were formed using λ-DNA tethers, core histones, and NAP1 and were exposed to forces

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