推荐产品
生物源
human
重組細胞
expressed in baculovirus infected Sf9 cells
化驗
≥70% (SDS-PAGE)
形狀
buffered aqueous glycerol solution
分子量
~83 kDa
NCBI登錄號
應用
cell analysis
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... KAT8(84148)
一般說明
Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). MYST1 has a chromodomain that is involved in protein-protein interactions and targeting transcriptional regulators to the chromatin.
生化／生理作用
Lysine acetyltransferase 8 (KAT8) or MYST histone acetyltransferase 1 (MYST1) was originally isolated as a human immunodeficiency virus-1 (HIV-1) TAT-interactive protein, which plays important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and non-histone proteins. MYST1 is also involved in ataxia-telangiectasia mutated (ATM) function. It acetylates histone 4-lysine 16 (H4K16). The protein is a modulator of embryonic stem cells and an epigenetic regulator. It has been associated with gastric carcinoma.
外觀
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
準備報告
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.
Gupta A
Cell Reports, 8(1), 177-189 (2014)
Expression of hMOF, but not HDAC4, is responsible for the global histone H4K16 acetylation in gastric carcinoma.
Zhu L
International Journal of Oncology, 46(6), 2535-2545 (2015)
The Histone Acetyltransferase MOF Promotes Induces Generation of Pluripotent Stem Cells.
Mu X
Cellular Reprogramming, 17(4), 259-267 (2015)
Arun Gupta et al.
Molecular and cellular biology, 25(12), 5292-5305 (2005-06-01)
We have determined that hMOF, the human ortholog of the Drosophila MOF gene (males absent on the first), encoding a protein with histone acetyltransferase activity, interacts with the ATM (ataxia-telangiectasia-mutated) protein. Cellular exposure to ionizing radiation (IR) enhances hMOF-dependent acetylation
K C Neal et al.
Biochimica et biophysica acta, 1490(1-2), 170-174 (2000-04-29)
We have identified a novel human gene product, hMOF, which exhibits significant similarity to the Drosophila dosage compensation regulator, MOF. A recombinant C-terminal portion of hMOF has histone acetyltransferase activity directed toward histones H3, H2A and H4, a specificity characteristic
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门