生物来源
human
重组
expressed in E. coli
方案
≥70% (SDS-PAGE)
表单
buffered aqueous glycerol solution
分子量
~56 kDa
NCBI登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... NFKBIB(4793)
一般描述
IκBβ is part of the NFκB complex and it inactivates NFκB complex by binding to it and trapping it in the cytoplasm. Phosphorylation of serine residues on IκBβ mediated by IκB kinases leads to its destruction via the ubiquitination pathway thereby allowing activation of the NFκB complex which translocates into the nucleus and binds DNA at kappa-B-binding motifs. The PEST domain of IkBβ can interact with two proteins KBRAS1 and KBRAS2 and this interaction can decrease the rate of degradation IκBβ. IκBβ has been shown to participate in multiple signaling pathways including adipocytokine signaling pathway, B-cell receptor signaling pathway, T-cell receptor signaling pathway and Hypoxia.
外形
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
制备说明
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Alexander Hoffmann et al.
Science (New York, N.Y.), 298(5596), 1241-1245 (2002-11-09)
Nuclear localization of the transcriptional activator NF-kappaB (nuclear factor kappaB) is controlled in mammalian cells by three isoforms of NF-kappaB inhibitor protein: IkappaBalpha, -beta, and - epsilon. Based on simplifying reductions of the IkappaB-NF-kappaB signaling module in knockout cell lines
C Fenwick et al.
Science (New York, N.Y.), 287(5454), 869-873 (2000-02-05)
Small guanosine triphosphatases, typified by the mammalian Ras proteins, play major roles in the regulation of numerous cellular pathways. A subclass of evolutionarily conserved Ras-like proteins was identified, members of which differ from other Ras proteins in containing amino acids
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