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生物源
human
重組細胞
expressed in E. coli
化驗
≥90% (HPLC)
≥90% (SDS-PAGE)
形狀
lyophilized powder
分子量
~47.0 kDa
包裝
pkg of 25 μg
儲存條件
avoid repeated freeze/thaw cycles
雜質
endotoxin, tested
NCBI登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... SPA12(145264)
一般說明
Vaspin (visceral adipose-specific SERPIN), a newly identified adipokine, is a member of serine protease inhibitor family. It is also known as serpin family A member 12 (SERPINA12). The gene encoding this protein is localized on human chromosome 14q32.13. Recombinant human Vaspin produced in E. coli is a single, non-glycosylated polypeptide chain containing 415 amino acids and having a molecular mass of 47kDa.
生化／生理作用
Vaspin (visceral adipose-specific SERPIN) is also a unique insulin sensitizing adipocytokine in obesity. A recent publication indicates that induction of human vaspin mRNA expression in adipose tissue is regulated in a fat depot-specific manner and could be associated with parameters of obesity, insulin resistance, and glucose metabolism. This protein may be useful as a biomarker with patients with acute myocardial infarction. It is a ligand of the 78kDa glucose-regulated protein/murine transmembrane protein (GRP78/MTJ-1) complex and has indirect effects on endoplasmic reticulum stress-induced metabolic disorders.
外觀
1 mg/ml in 20 mM Tris pH-8, 0.2 mM PMSF and 10% glycerol.
重構
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
nwg
Feihong Yang et al.
Biochemical and biophysical research communications, 503(2), 501-507 (2018-05-08)
Visceral adipose tissue-derived serine protease inhibitor (vaspin), as a secretory adipokine, was reported to exert a protective role on insulin resistance. Recent studies showed that serum vaspin level was downregulated in patients with coronary artery disease. However, whether vaspin exerted
Vaspin as a Prognostic Marker in Patients with Acute Myocardial Infarction.
Zhang B
Heart, Lung & Circulation, 25(3), 257-264 (2016)
Vaspin: a novel adipokine, member of the family of serine protease inhibitors
Ekaterini Koiou
Aristotle University Medical Journal, 38.3, 7-18 (2011)
The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis.
Dimova R and Tankova T
BioMed Research International, 823481-823481 (2015)
S Kameshima et al.
Acta physiologica (Oxford, England), 216(2), 203-210 (2015-08-13)
Visceral adipose tissue-derived serine protease inhibitor (vaspin) is an adipocytokine with insulin-sensitizing activity originally identified in visceral adipose tissues of obesity-related type II diabetic rats. We previously showed that vaspin inhibits vascular cell migration and apoptosis as well as inflammatory
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