生物来源
rat
重组
expressed in E. coli
方案
≥98% (HPLC)
≥98% (SDS-PAGE)
表单
lyophilized
效能
<10 ng/mL ED50
分子量
~15.8kDa
包装
pkg of 10 μg
杂质
endotoxin, tested
NCBI登记号
运输
wet ice
储存温度
−20°C
基因信息
rat ... Il3(24495)
一般描述
Interleukin-3 (IL-3) is a species-specific colony-stimulating factor that stimulates colony formation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. Recombinant rat IL-3 is a 15.8 kDa protein.
外形
Sterile filtered and lyophilized from 5 mM sodium citrate, pH 4.0.
重悬
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 μg/μL. The solution can be diluted into other aqueous buffers.
Weidong Yu et al.
Carcinogenesis, 29(9), 1717-1724 (2008-05-06)
Abl interactor (Abi) 1 was first identified as the downstream target of Abl tyrosine kinases and was found to be dysregulated in leukemic cells expressing oncogenic Bcr-Abl and v-Abl. Although the accumulating evidence supports a role of Abi1 in actin
Kerstin Kapp et al.
Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)
Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist
Orit Uziel et al.
Biochemical and biophysical research communications, 450(1), 274-282 (2014-06-08)
Treatment with erythropoietin (EPO) in several cancers is associated with decreased survival due to cancer progression. Due to the major importance of telomerase in cancer biology we hypothesized that some of these effects may be mediated through EPO effect on
Cristina Ghirelli et al.
Cancer research, 75(14), 2775-2787 (2015-05-16)
Reciprocal interactions between tumor cells and their microenvironment vitally impact tumor progression. In this study, we show that GM-CSF produced by primary breast tumor cells induced the activation of plasmacytoid predendritic cells (pDC), a cell type critical to anti-viral immunity.
Attila Szabo et al.
Immunology and cell biology, 92(8), 671-678 (2014-05-21)
Plasmacytoid dendritic cells (pDCs) are professional type I interferon (IFN)-producing cells that play an essential role in antiviral immunity. In many cell types, detection of intracellular pathogens is mostly dependent on endosomal Toll-like receptors (TLRs) and cytosolic sensors, such as
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