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生物源
human
重組細胞
expressed in baculovirus infected Sf9 cells
化驗
≥70% (SDS-PAGE)
形狀
aqueous solution
分子量
62 kDa
包裝
pkg of 10 μg
技術
activity assay: suitable
inhibition assay: suitable
溶解度
soluble
water: soluble
NCBI登錄號
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
human ... PDGFRB(5159)
一般說明
Research area: Cell Cycle
Human PDGFRbeta (GenBank Accession No. NM_002609), cytoplasmic domain, amino acids 558-1106 (end) with N-terminal His-tag, MW= 62 kDa, expressed in Sf9 cells via a Baculovirus expression system.
Platelet-derived growth factor receptor (PDGFR) belongs to subclass III of receptor tyrosine kinases. The PDGFR exists as two isoforms, PDGFa and PDGFb-receptors, consisting of five extracellular immunoglobulin (Ig) loops and an intracellular tyrosine kinase (TK) domain.
Human PDGFRbeta (GenBank Accession No. NM_002609), cytoplasmic domain, amino acids 558-1106 (end) with N-terminal His-tag, MW= 62 kDa, expressed in Sf9 cells via a Baculovirus expression system.
Platelet-derived growth factor receptor (PDGFR) belongs to subclass III of receptor tyrosine kinases. The PDGFR exists as two isoforms, PDGFa and PDGFb-receptors, consisting of five extracellular immunoglobulin (Ig) loops and an intracellular tyrosine kinase (TK) domain.
應用
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
生化／生理作用
The PDGFβ receptor is involved in the development of the kidney, heart, placenta, blood vessels, and cardiovascular system. It also helps to regulate interstitial fluid pressure in tissues thus preventing edema. The activation of the PDGFβ receptor plays a crucial role in the process of wound healing. In addition to these functions, its overexpression is related to gastric cancer.
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
The PDGF family: four gene products form five dimeric isoforms
Fredriksson, Linda and Li, Hong and Eriksson, Ulf
Cytokine & Growth Factor Reviews, 15(4) (2004)
PDGFRB is a potential prognostic biomarker and correlated with immune infiltrates in gastric cancer
Liu B, et al.
Cancer Biomarkers : Section A of Disease Markers, 34(2), 251-264 (2022)
Drug targeting to myofibroblasts: Implications for fibrosis and cancer
Yazdani S, et al.
Advanced Drug Delivery Reviews, 121, 101-116 (2017)
C H Heldin et al.
Physiological reviews, 79(4), 1283-1316 (1999-10-03)
Platelet-derived growth factor (PDGF) is a major mitogen for connective tissue cells and certain other cell types. It is a dimeric molecule consisting of disulfide-bonded, structurally similar A- and B-polypeptide chains, which combine to homo- and heterodimers. The PDGF isoforms
L Claesson-Welsh et al.
Molecular and cellular biology, 8(8), 3476-3486 (1988-08-01)
The structure of the human receptor for platelet-derived growth factor (PDGF) has been deduced through cDNA cloning. A 5.45-kilobase-pair cDNA clone predicts a 1,106-amino-acid polypeptide, including the cleavable signal sequence. The overall amino acid sequence similarity with the murine PDGF
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