品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
, White to light brown
溶解度
DMSO: 2 mg/mL, clear
儲存溫度
-10 to -25°C
SMILES 字串
O=C(N)C1=C(NC(C2CCCCC2)=O)SC(NC3=CC=CC=C3)=N1
生化／生理作用
Inhibitor of phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C).
UNC3230 is a selective inhibitor of the lipid kinase phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C) with an IC50 of 41 nM. UNC3230 showed selectivity for PIP5K1C and PIP4K2C (phosphatidylinositol 5-phosphate 4-kinase, type II, gamma) and did not inhibit PIP5K1A or any of the other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 4,5-bisphosphate 3-kinases (PIK3s, also known as PI3Ks). UNC3230 lowered PIP2 levels in nociceptive dorsal root ganglia (DRG) neurons and had antinociceptive effects when injected intrathecally as well as peripherally into the hindpaw, indicating that either central or peripheral inhibition of PIP5K1C can reduce nociceptive responses.
UNC3230 is a selective inhibitor of the lipid kinase phosphatidylinositol 4-phosphate 5 kinase type 1C (PIP5K1C) with an IC50 of 41 nM. UNC3230 showed selectivity for PIP5K1C and PIP4K2C (phosphatidylinositol 5-phosphate 4-kinase, type II, gamma) and did not inhibit PIP5K1A or any of the other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 4,5-bisphosphate 3-kinases (PIK3s, also known as PI3Ks). UNC3230 lowered PIP2 levels in nociceptive dorsal root ganglia (DRG) neurons and had antinociceptive effects when injected intrathecally as well as peripherally into the hindpaw, indicating that either central or peripheral inhibition of PIP5K1C can reduce nociceptive responses.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Yukino Kato et al.
Experimental cell research, 405(1), 112654-112654 (2021-05-28)
Oligodendroglial cells (oligodendrocytes) differentiate to form the myelin that wraps neuronal axons in the central nervous system (CNS). This myelin sheath supports the propagation of saltatory conduction and protects axons from physical stresses. When oligodendrocytes do not normally differentiate to
Brittany D Wright et al.
Neuron, 82(4), 836-847 (2014-05-24)
Numerous pain-producing (pronociceptive) receptors signal via phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis. However, it is currently unknown which lipid kinases generate PIP2 in nociceptive dorsal root ganglia (DRG) neurons and if these kinases regulate pronociceptive receptor signaling. Here, we found that phosphatidylinositol
Andrey A Parkhitko et al.
PLoS genetics, 17(2), e1009354-e1009354 (2021-02-17)
The RB1 tumor suppressor is recurrently mutated in a variety of cancers including retinoblastomas, small cell lung cancers, triple-negative breast cancers, prostate cancers, and osteosarcomas. Finding new synthetic lethal (SL) interactions with RB1 could lead to new approaches to treating
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