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品質等級
化驗
≥98% (HPLC)
形狀
powder
顏色
white to beige
溶解度
DMSO: 0.5 mg/mL, clear (Warmed)
儲存溫度
room temp
SMILES 字串
O=C(/C=C/C1=CC=CN=C1)C2=CC=C(C(/C=C/C3=CC=CN=C3)=O)C=C2
生化／生理作用
Mitochondrial fission inhibitor that blocks DRP1 recruitment to mitochondria.
DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.
DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction
Cell Chemical Biology, 30(3) (2023)
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