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生化/生理作用
Potent and selective ecto-5′-nucleotidase (CD73, eN) Inhibitor.
PSB12379 is a potent and selective ecto-5′-nucleotidase (CD73, eN) Inhibitor (recombinant human/rat eN Ki = 2.21/9.03 nM; human serum eN Ki = 18.8 nM; Ki >>10 μM against NTPDase 1/2/3 & NPP 1/2/3). Umbilical cord mesenchymal stem cell-derived small extracellular vesicles (UCMSC-sEV) is reported to promote the proliferation and migration of pediatric urethral smooth muscle cells (PUSMCs) in cultures by CD73-catalyzed production of adenosine, which can be blocked by PSB12379.
PSB12379 is a potent and selective ecto-5′-nucleotidase (CD73, eN) Inhibitor (recombinant human/rat eN Ki = 2.21/9.03 nM; human serum eN Ki = 18.8 nM; Ki >>10 μM against NTPDase 1/2/3 & NPP 1/2/3). Umbilical cord mesenchymal stem cell-derived small extracellular vesicles (UCMSC-sEV) is reported to promote the proliferation and migration of pediatric urethral smooth muscle cells (PUSMCs) in cultures by CD73-catalyzed production of adenosine, which can be blocked by PSB12379.
注意
Hygroscopic
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
CD73-Positive Small Extracellular Vesicles Derived From Umbilical Cord Mesenchymal Stem Cells Promote the Proliferation and Migration of Pediatric Urethral Smooth Muscle Cells Through Adenosine Pathway
Frontiers in Bioengineering and Biotechnology, 10, 895998-895998 (2022)
A Body of Circumstantial Evidence for the Irreversible Ectonucleotidase Inhibitory Action of FSCPX, an Agent Known as a Selective Irreversible A1 Adenosine Receptor Antagonist So Far
International Journal of Molecular Sciences, 22(18), 9831-9831 (2021)
?,?-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors
Journal of medicinal chemistry, 58(15), 6248-6263 (2015)
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