推荐产品
品質等級
化驗
≥98% (HPLC)
形狀
oil
顏色
colorless to yellow
儲存溫度
2-8°C
SMILES 字串
O=P(C(C)C)(C(C)C)CCCCCCCCC
InChI 密鑰
DHOTYMJGZIUWRT-UHFFFAOYSA-N
生化／生理作用
Cryosim-3 is a water soluble, selective and potent agonist of TRPM8 (transient receptor potential melastatin 8) receptor. Cryosim-3 increases tear secretion in an animal model of dry eye disease. Also it relieves ocular discomfort in subjects diagnosed with DED without eye irritation.
Water soluble, selective and potent agonist of TRPM8 receptor
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Ying Yin et al.
Science (New York, N.Y.), 378(6616), eadd1268-eadd1268 (2022-10-14)
The transient receptor potential melastatin 8 (TRPM8) channel is the primary molecular transducer responsible for the cool sensation elicited by menthol and cold in mammals. TRPM8 activation is controlled by cooling compounds together with the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2).
Jee Myung Yang et al.
BMC ophthalmology, 17(1), 101-101 (2017-06-28)
Physical cooling of the eye surface relieves ocular discomfort, but translating this event to drug treatment of dry eye discomfort not been studied. Here, we synthesized a water-soluble TRPM8 receptor agonist called cryosim-3 (C3, 1-diisopropylphosphorylnonane) which selectively activates TRPM8 (linked
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